Phenotypes associated with this allele

• Allele Symbol: Sqstm1^tm1Hwl
• Allele Name: targeted mutation 1, Han-Woong Lee
• Allele ID: MGI:5313263
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sqstm1^tm1Hwl/Sqstm1^tm1Hwl	B6.129P2-Sqstm1^tm1Hwl	MGI:5313289

Genotype
MGI:5313289

hm1

• Allelic Composition: Sqstm1^tm1Hwl/Sqstm1^tm1Hwl
• Genetic Background: B6.129P2-Sqstm1^tm1Hwl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:181228 )

• mean and maximal lifespan of male mice are 68 and 115 weeks, respectively

• reduced lifespan in female mice is not as much as in male mice

premature aging ( J:181228 )

• premature lordokyphosis, rough fur coat and thinning of the subcutaneous adipose layer in the dorsal skin

cellular

abnormal mitochondrial physiology ( J:181228 )

• mitochondrial produce more hydrogen peroxide compared to in wild-type cells

• male mice exhibit a faster rate of mitochondrial dysfunction compared with female mice

abnormal respiratory electron transport chain ( J:181228 )

• mitochondria exhibited decreased rates of both state 2 and state 3 respiration, indicating a compromised mitochondrial electron transport

oxidative stress ( J:181228 )

• the ratio of oxidized glutathione (GS/GSSG) is reduced compared to in wild-type mice

integument

decreased subcutaneous adipose tissue amount ( J:181228 )

• prematurely

rough coat ( J:181228 )

• prematurely

homeostasis/metabolism

decreased oxygen consumption ( J:181228 )

• at 27 and 40 weeks

adipose tissue

decreased subcutaneous adipose tissue amount ( J:181228 )

• prematurely

skeleton

lordokyphosis ( J:181228 )

• premature lordokyphosis