Sqstm1^tm1Hwl
Targeted Allele Detail

Summary

• Symbol: Sqstm1^tm1Hwl
• Name: sequestosome 1; targeted mutation 1, Han-Woong Lee
• MGI ID: MGI:5313263
• Gene: Sqstm1 Location: Chr11:50090193-50101654 bp, - strand Genetic Position: Chr11, 30.36 cM, cytoband B1.2
• Alliance: Sqstm1^tm1Hwl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181228
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neo cassette. Western blot analysis confirmed the absence of protein expression in the brain, liver and pancreas. (J:181228)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sqstm1 Mutation: 32 strains or lines available

References

• Original: J:181228 Kwon J, et al., Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade. EMBO Rep. 2012 Feb 1;13(2):150-6
• All: 7 reference(s)