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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gstk1tm1Pgb
targeted mutation 1, Philip G Board
MGI:5294676
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gstk1tm1Pgb/Gstk1tm1Pgb BALB/c-Gstk1tm1Pgb MGI:5294785


Genotype
MGI:5294785
hm1
Allelic
Composition
Gstk1tm1Pgb/Gstk1tm1Pgb
Genetic
Background
BALB/c-Gstk1tm1Pgb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gstk1tm1Pgb mutation (1 available); any Gstk1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• male mice exhibit a different shaped survival curve compared with wild-type mice
• over 1 year, fewer male mice die of heart pathologies compared with wild-type mice
• however, female mice exhibit normal survival curve
• at 6 months, male mice exhibit increased death due to kidney or urinary tract pathologies compared with wild-type mice

reproductive system

renal/urinary system
N
• kidney tubules are normal
• microalbuminuria at 12 and 26 weeks of age
• dexamethasone treatment does not improve albumin to creatinine levels
• however, microalbuminuria is the same as in wild-type mice at 45 to 48 weeks of age
• urethra inflammed in mice that die of kidney or urinary tract pathologies
• in mice that die of kidney or urinary tract pathologies
• in male and female mice at 5 to 6 months of age
• at 3 months, glomerular basement membrane changes include laminations, splits, subepithelial protrusions, and lucent areas
• at 3 months, male and female mice develop glomerular nephropathy with glomerular basement membrane changes
• dexamethasone treatment does not improve abnormal glomerulus morphology
• in mice that die of kidney or urinary tract pathologies
• in mice that die of kidney or urinary tract pathologies

homeostasis/metabolism
• at 25 weeks of age but not in older mice
• microalbuminuria at 12 and 26 weeks of age
• dexamethasone treatment does not improve albumin to creatinine levels
• however, microalbuminuria is the same as in wild-type mice at 45 to 48 weeks of age

immune system
• at 25 weeks of age but not in older mice
• urethra inflammed in mice that die of kidney or urinary tract pathologies
• in mice that die of kidney or urinary tract pathologies

cellular
N
• mice exhibit little or no oxidative stress

endocrine/exocrine glands

hematopoietic system
• at 25 weeks of age but not in older mice





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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory