Phenotypes associated with this allele

• Allele Symbol: Gstk1^tm1Pgb
• Allele Name: targeted mutation 1, Philip G Board
• Allele ID: MGI:5294676
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gstk1^tm1Pgb/Gstk1^tm1Pgb	BALB/c-Gstk1^tm1Pgb	MGI:5294785

Genotype
MGI:5294785

hm1

• Allelic Composition: Gstk1^tm1Pgb/Gstk1^tm1Pgb
• Genetic Background: BALB/c-Gstk1^tm1Pgb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal survival ( J:177201 )

• male mice exhibit a different shaped survival curve compared with wild-type mice

• over 1 year, fewer male mice die of heart pathologies compared with wild-type mice

• however, female mice exhibit normal survival curve

premature death ( J:177201 )

• at 6 months, male mice exhibit increased death due to kidney or urinary tract pathologies compared with wild-type mice

reproductive system

increased testis weight ( J:177201 )

♂

renal/urinary system

renal/urinary system phenotype ( J:177201 )

N • kidney tubules are normal

increased kidney weight ( J:177201 )

increased urine microalbumin level ( J:177201 )

• microalbuminuria at 12 and 26 weeks of age

• dexamethasone treatment does not improve albumin to creatinine levels

• however, microalbuminuria is the same as in wild-type mice at 45 to 48 weeks of age

urethritis ( J:177201 )

• urethra inflammed in mice that die of kidney or urinary tract pathologies

urinary bladder inflammation ( J:177201 )

• in mice that die of kidney or urinary tract pathologies

podocyte foot process effacement ( J:177201 )

• in male and female mice at 5 to 6 months of age

abnormal renal glomerulus basement membrane morphology ( J:177201 )

• at 3 months, glomerular basement membrane changes include laminations, splits, subepithelial protrusions, and lucent areas

abnormal renal glomerulus morphology ( J:177201 )

• at 3 months, male and female mice develop glomerular nephropathy with glomerular basement membrane changes

• dexamethasone treatment does not improve abnormal glomerulus morphology

glomerulonephritis ( J:177201 )

distended urinary bladder ( J:177201 )

• in mice that die of kidney or urinary tract pathologies

urinary bladder obstruction ( J:177201 )

• in mice that die of kidney or urinary tract pathologies

homeostasis/metabolism

decreased circulating triglyceride level ( J:177201 )

• at 25 weeks of age but not in older mice

decreased adiponectin level ( J:177201 )

• slightly

increased urine microalbumin level ( J:177201 )

• microalbuminuria at 12 and 26 weeks of age

• dexamethasone treatment does not improve albumin to creatinine levels

• however, microalbuminuria is the same as in wild-type mice at 45 to 48 weeks of age

immune system

decreased spleen red pulp amount ( J:177201 )

• at 25 weeks of age but not in older mice

decreased spleen weight ( J:177201 )

glomerulonephritis ( J:177201 )

urethritis ( J:177201 )

• urethra inflammed in mice that die of kidney or urinary tract pathologies

urinary bladder inflammation ( J:177201 )

• in mice that die of kidney or urinary tract pathologies

cellular

cellular phenotype ( J:177201 )

N • mice exhibit little or no oxidative stress

endocrine/exocrine glands

increased testis weight ( J:177201 )

♂

hematopoietic system

decreased spleen red pulp amount ( J:177201 )

• at 25 weeks of age but not in older mice

decreased spleen weight ( J:177201 )

growth/size/body

increased kidney weight ( J:177201 )