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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdkn1ctm2.1Kei
targeted mutation 2.1, Keiichi I Nakayama
MGI:5294426
Summary 4 genotypes


Genotype
MGI:5294431
ht1
Allelic
Composition		 Cdkn1ctm2.1Kei/Cdkn1c+
Genetic
Background		 B6.129P2-Cdkn1ctm2.1Kei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1ctm2.1Kei mutation (1 available); any Cdkn1c mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:176209 )
• mice are indistinguishable from wild-type mice




Genotype
MGI:5294434
cn2
Allelic
Composition		 Cdkn1atm1Led/Cdkn1atm1Led
Cdkn1ctm2.1Kei/Cdkn1c+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 B6.Cg-Cdkn1ctm2.1Kei Cdkn1atm1Led Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Led mutation (1 available); any Cdkn1a mutation (60 available)
Cdkn1ctm2.1Kei mutation (1 available); any Cdkn1c mutation (19 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic stem cell physiology ( J:176209 )
• when Cdkn1ctm2.1Kei is inherited maternally, hematopoietic stem (KSL) cells from pIpC-treated mice exhibit reduced colony formation in vitro before and after coculture with OP9 cells compared with control cells




Genotype
MGI:5294432
cn3
Allelic
Composition		 Cdkn1ctm2.1Kei/Cdkn1c+
Tg(EIIa-cre)C5379Lmgd/0
Genetic
Background		 B6.Cg-Cdkn1ctm2.1Kei Tg(EIIa-cre)C5379Lmgd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1ctm2.1Kei mutation (1 available); any Cdkn1c mutation (19 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
kidney papillary atrophy ( J:176209 )
• when Cdkn1ctm2.1Kei is inherited maternally, mice exhibit atrophy of the renal papilla compared with control mice




Genotype
MGI:5294433
cn4
Allelic
Composition		 Cdkn1ctm2.1Kei/Cdkn1c+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 B6.Cg-Cdkn1ctm2.1Kei Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1ctm2.1Kei mutation (1 available); any Cdkn1c mutation (19 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased hematopoietic stem cell number ( J:176209 )
• when Cdkn1ctm2.1Kei is inherited maternally, mice exhibit decreased KSL fractions as early as 4 weeks after pIpC-treatment compared with control mice
abnormal hematopoietic stem cell physiology ( J:176209 )
• when Cdkn1ctm2.1Kei is inherited maternally, hematopoietic stem cells from pIpC-treated mice exhibit decreased self-renewal capacity, decreased maintenance of quiescence, and increased frequency of apoptosis compared with control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory