All Phenotypes Tg(Tpbpa-cre,-EGFP)5Jcc MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Notch2^tm3Grid/Notch2^tm3Grid Tg(Tpbpa-cre,-EGFP)5Jcc/0	involves: 129S1/Sv	MGI:5288006
cn2	Rr27^tm1Kpfe/Rr27⁺ Tg(Tpbpa-cre,-EGFP)5Jcc/0	involves: 129S1/Sv * 129X1/SvJ	MGI:7287525
cn3	E2f7^tm1Gle/E2f7^tm1Gle E2f8^tm1Gle/E2f8^tm1Gle Tg(Tpbpa-cre,-EGFP)5Jcc/0	involves: 129S6/SvEvTac	MGI:5473263

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal placenta vasculature ( J:173527 )

• trophoblast giant cells and glycogen trophoblast cells fail to invade maternal spiral arterioles at E12.5 indicating a failure of endovascular invasion

• trophoblast-lined canals in the placenta that transport maternal blood to the labyrinth are reduced in size by 30-40%

• placentas fail to remodel maternal blood vessels adequately resulting in reduced placental perfusion by about 23% in mutants

ovary hemorrhage ( J:173527 )

embryo

abnormal placenta vasculature ( J:173527 )

• trophoblast giant cells and glycogen trophoblast cells fail to invade maternal spiral arterioles at E12.5 indicating a failure of endovascular invasion

• trophoblast-lined canals in the placenta that transport maternal blood to the labyrinth are reduced in size by 30-40%

• placentas fail to remodel maternal blood vessels adequately resulting in reduced placental perfusion by about 23% in mutants

endocrine/exocrine glands

ovary hemorrhage ( J:173527 )

abnormal ovary morphology ( J:173527 )

• females exhibit severe ovarian defects

ovarian follicular cyst ( J:173527 )

reproductive system

ovary hemorrhage ( J:173527 )

abnormal ovary morphology ( J:173527 )

• females exhibit severe ovarian defects

ovarian follicular cyst ( J:173527 )

abnormal pregnancy ( J:173527 )

• homozygous mothers mated with homozygous males exhibit a loss of embryos as early as E9.5, with 54% resorption between E11.5 and E14.5

• homozygous mothers mated with heterozygous males and heterozygous mothers mated with homozygous males exhibit a similar loss of both heterozygous and homozygous embryos, indicating that lethality is not due to maternal factors and is correlated with the presence of homozygous embryos rather than the genotype of individual embryos

• homozygous mothers have fewer implantation sites than controls

growth/size/body

ovarian follicular cyst ( J:173527 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pre-eclampsia		DOID:10591	OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592	J:173527

Allelic Composition	Rr27^tm1Kpfe/Rr27⁺ Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr27^tm1Kpfe mutation (0 available); any Rr27 mutation (6 available)
Tg(Tpbpa-cre,-EGFP)5Jcc mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:325552 )

N	• normal fetal and placental weight • born at expected Mendelian ratios

abnormal trophoblast giant cell morphology ( J:325552 )

• 96% volume increase of trophoblast giant cells (TGC) in females

abnormal maternal decidual layer morphology ( J:325552 )

• reduced volume

abnormal placenta junctional zone morphology ( J:325552 , J:325552 , J:325552 )

	• 3x increase in cell proliferation (J:325552) • normal apoptosis (J:325552)
	• 43% volume increase in females (J:325552) • 51% volume increase of glycogen cells (GC), 33% of spongiotrophoblasts (SpT) and 96% of trophoblast giant cells (TGC) in females (J:325552) • 63% increase in number of glycogen cells (GC) in females (J:325552) • normal distribution and size of glycogen cells (GC) and and spongiotrophoblasts (SpT) in females (J:325552)
	• 20% volume increase in males (J:325552) • 22% spongiotrophoblast (SpT) volume increase in males (J:325552) • normal distribution and size of spongiotrophoblasts (SpT) and distribution, number and size of glycogen cells (GC) in males (J:325552)

increased spongiotrophoblast cell number ( J:325552 , J:325552 )

	• 44% increase in spongiotrophoblast cell number in females (J:325552)
	• 34% increase in spongiotrophoblast cell number in males (J:325552)

decreased placental labyrinth size ( J:325552 )

reproductive system

abnormal maternal decidual layer morphology ( J:325552 )

• reduced volume

growth/size/body

growth/size/body region phenotype ( J:325552 )

N	• normal fetal and placental weight

Allelic Composition	E2f7^tm1Gle/E2f7^tm1Gle E2f8^tm1Gle/E2f8^tm1Gle Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7^tm1Gle mutation (0 available); any E2f7 mutation (32 available)
E2f8^tm1Gle mutation (0 available); any E2f8 mutation (34 available)
Tg(Tpbpa-cre,-EGFP)5Jcc mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:183999 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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