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Allele Symbol Allele Name Allele ID |
Tg(BEST1-HTRA1)#Ybf transgene insertion, Yingbin Fu MGI:5285549 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Similar development of polypoidal choroidal vasculopathy in Htra1tm1Ybf/Htra1tm1Ybf Tg(BEST1-HTRA1)#Ybf/0 mice as in Tg(BEST1-HTRA1)#Ybf/0 mice
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• defects resembling polypoidal choroidal vasculopathy (PCV) are seen
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• small hyperfluorescent dots consistent with microaneurysmal dilations are seen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Tg(BEST1-HTRA1)#Ybf/0 mice develop polypoidal choroidal vasculopathy
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• pools of blood cells are frequently present in the sub-retinal pigment epithelial space apparently from hemorrhagic choroidal vessels
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• in PCV+ mice
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• in PCV+ mice
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• degenerative changes (disorganized inner and outer segments, vacuolization of inner segments) are seen in PCV+ mice
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• degenerative changes (vacuoles, areas with loss of basal infolding, areas of hyper and hypo-pigmentation) are seen in PCV+ mice
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• defects resembling polypoidal choroidal vasculopathy (PCV) are seen in 59% of mice starting at 3 - 5 weeks of age
• the severity of the PCV phenotype varies from weak to severe
• large polypoidal lesions (diameter more than 0.45 mm) resembling grape clusters are seen at 3 - 5 weeks of age in some mice
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• a network of branching abnormal vessels (i.e., loop or coil-like structures) with terminal dilations is seen at 3 - 5 weeks of age in some mice
• some branching vascular networks and lesions develop new lesions after 2 to 5 months
at 11 months of age clusters of dilated, thin-wall vessels are seen
some branching vascular networks and lesions develop new lesions after 2 to 5 months
• at 11 months of age clusters of dilated, thin-wall vessels are seen
• at 11 months of age in atrophic regions choroidal arteries completely lack both the elastic interna and elastic externa and the tunica media is severely degenerated or absent
• however, neighboring retinal vessels are normal
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• in 50% of mice with PCV over 11 months of age, lesions resembling occult choroidal neovascularization are seen
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• the integrity of the elastic lamina is severely compromised with choroidal endothelial processes inserting into the gaps in the elatic lamina in PCV+ mice
• membrane bound basal linear deposits are seen in both the inner and outer collagenous layers
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• a network of branching abnormal vessels (i.e., loop or coil-like structures) with terminal dilations is seen at 3 - 5 weeks of age in some mice
• some branching vascular networks and lesions develop new lesions after 2 to 5 months
at 11 months of age clusters of dilated, thin-wall vessels are seen
some branching vascular networks and lesions develop new lesions after 2 to 5 months
• at 11 months of age clusters of dilated, thin-wall vessels are seen
• at 11 months of age in atrophic regions choroidal arteries completely lack both the elastic interna and elastic externa and the tunica media is severely degenerated or absent
• however, neighboring retinal vessels are normal
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• in 50% of mice with PCV over 11 months of age, lesions resembling occult choroidal neovascularization are seen
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• numerous small hyperfluorescent dots (diameter less than 0.25 mm) consistent with microaneurysmal dilations are seen at 3 - 5 weeks of age in most mice
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• pools of blood cells are frequently present in the sub-retinal pigment epithelial space apparently from hemorrhagic choroidal vessels
|
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• degenerative changes (vacuoles, areas with loss of basal infolding, areas of hyper and hypo-pigmentation) are seen in PCV+ mice
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• in PCV+ mice
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• in PCV+ mice
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• degenerative changes (disorganized inner and outer segments, vacuolization of inner segments) are seen in PCV+ mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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