Analysis Tools
mortality/aging
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• mice do not survive beyond P24
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nervous system
| N |
• granule cell proliferation is normal
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• in the cerebellum and cerebrum at P7
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• at P14, cerebellum morphology is severely compromised along the anteroposterior axis compared with wild-type mice
• however, morphology is normal at E16.5
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• at E18.5, cerebellar foliation is abnormal compared with wild-type mice
• at P5, the cerebella lacks uvular sulcus 1 unlike wild-type mice
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• at P7, dendritogenesis in the cerebella is retarded compared to in wild-type mice
• at P7 and P14, dendritic length is less than in wild-type mice
• at P14, dendritic arbors are less elaborate with fewer primary and secondary branches than in wild-type mice
• however, Purkinje cell dendrite length is restored by P14
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• mice exhibit abnormal granule cell maturation compared with wild-type mice
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• at P18, lobule IX is missing the uvular sulcus 1 unlike in wild-type mice
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• extra fissure at P5
• divided in two at P14
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• in the molecular layer at P7
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behavior/neurological
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• mice maintain body balance by spreading their limbs farther apart than wild-type mice
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• at P18
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• mice exhibit irregular step alternation compared with wild-type mice
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• at 1 week of age, mice walk slowly and often lose their balance and stop unlike wild-type mice
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growth/size/body
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• by P7
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• by P7, mice exhibit an inability to gain body weight unlike wild-type mice
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cellular
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• in the cerebellum and cerebrum at P7
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