Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Map2k7tm1.1Twad mutation
(0 available);
any
Map2k7 mutation
(19 available)
Map2k7tm1.2Twad mutation
(0 available);
any
Map2k7 mutation
(19 available)
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mortality/aging
neoplasm
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• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice
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cellular
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• following adenovirus cre infection, mice exhibit impaired DNA damage response compared with control mice
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homeostasis/metabolism
respiratory system
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• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice
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neoplasm
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• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice
• however, tumorigenesis is the same as in Map2k7tm1.1Twad/Map2k7tm1.2Twad Krastm4Tyj/Kras+ mice
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• following adenovirus cre infection, mice exhibit more adenocarcinomas than Map2k7tm1.1Twad/Map2k7tm1.2Twad Krastm4Tyj/Kras+ mice
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respiratory system
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• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice
• however, tumorigenesis is the same as in Map2k7tm1.1Twad/Map2k7tm1.2Twad Krastm4Tyj/Kras+ mice
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• following adenovirus cre infection, mice exhibit more adenocarcinomas than Map2k7tm1.1Twad/Map2k7tm1.2Twad Krastm4Tyj/Kras+ mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Map2k7tm1.1Twad mutation
(0 available);
any
Map2k7 mutation
(19 available)
Map2k7tm1.2Twad mutation
(0 available);
any
Map2k7 mutation
(19 available)
Tg(Trp53)bSrn mutation
(1 available)
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neoplasm
N |
• following adenovirus cre infection, mice exhibit the same tumor burden as in control mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k7tm1.1Twad mutation
(0 available);
any
Map2k7 mutation
(19 available)
Map2k7tm1.2Twad mutation
(0 available);
any
Map2k7 mutation
(19 available)
Tg(MMTV-cre)4Mam mutation
(1 available)
Tg(MMTV-Erbb2)1Pv mutation
(0 available)
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mortality/aging
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• compared with control mice
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neoplasm
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• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice
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integument
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• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice
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endocrine/exocrine glands
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• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k7tm1.1Twad mutation
(0 available);
any
Map2k7 mutation
(19 available)
Map2k7tm1.2Twad mutation
(0 available);
any
Map2k7 mutation
(19 available)
Tg(MMTV-cre)4Mam mutation
(1 available)
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reproductive system
N |
• mice exhibit normal mammary gland formation throughout puberty
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