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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		S1pr1tm1Jch
targeted mutation 1, Jerold Chun
MGI:4939069
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		S1pr1tm1Jch/S1pr1tm1Jch
Tg(Syn1-cre)671Jxm/? 		involves: C57BL/6J * CBA MGI:4939154
cn2
 		S1pr1tm1Jch/S1pr1tm1Jch
Tg(GFAP-cre)25Mes/? 		involves: C57BL/6J * FVB/N MGI:4939155
cn3
 		S1pr1tm1Jch/S1pr1tm1Jch
Tg(Nes-cre)1Kln/0 		involves: C57BL/6J * SJL MGI:4939153


Genotype
MGI:4939154
cn1
Allelic
Composition		 S1pr1tm1Jch/S1pr1tm1Jch
Tg(Syn1-cre)671Jxm/?
Genetic
Background		 involves: C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr1tm1Jch mutation (0 available); any S1pr1 mutation (30 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:168824 )
N
• response to Experimental Autoimmune Encephalitis induced by Myelin Oligodendrocyte Glycoprotein is similar to controls




Genotype
MGI:4939155
cn2
Allelic
Composition		 S1pr1tm1Jch/S1pr1tm1Jch
Tg(GFAP-cre)25Mes/?
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr1tm1Jch mutation (0 available); any S1pr1 mutation (30 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:168824 )
• Experimental Autoimmune Encephalitis induced by Myelin Oligodendrocyte Glycoprotein is attenuated but otherwise similar to contrtols

nervous system
astrocytosis ( J:168824 )
• does not develop in Experimental Autoimmune Encephalitis
abnormal axon morphology ( J:168824 )
• reduced axonal damage in Experimental Autoimmune Encephalitis
demyelination ( J:168824 )
• reduced in Experimental Autoimmune Encephalitis




Genotype
MGI:4939153
cn3
Allelic
Composition		 S1pr1tm1Jch/S1pr1tm1Jch
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr1tm1Jch mutation (0 available); any S1pr1 mutation (30 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:168824 )
• Experimental Autoimmune Encephalitis induced by Myelin Oligodendrocyte Glycoprotein is reduced in severity as compared to controls

nervous system
astrocytosis ( J:168824 )
• does not develop in Experimental Autoimmune Encephalitis
abnormal axon morphology ( J:168824 )
• reduced axonal damage in Experimental Autoimmune Encephalitis
demyelination ( J:168824 )
• reduced in Experimental Autoimmune Encephalitis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory