S1pr1^tm1Jch
Targeted Allele Detail

Summary

• Symbol: S1pr1^tm1Jch
• Name: sphingosine-1-phosphate receptor 1; targeted mutation 1, Jerold Chun
• MGI ID: MGI:4939069
• Synonyms: S1pr1^loxP
• Gene: S1pr1 Location: Chr3:115504082-115508704 bp, - strand Genetic Position: Chr3, 50.0 cM
• Alliance: S1pr1^tm1Jch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168824
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The entrire open reading frame is flanked by loxP sites. (J:168824)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any S1pr1 Mutation: 30 strains or lines available

References

• Original: J:168824 Choi JW, et al., FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):751-6
• All: 10 reference(s)