Phenotypes associated with this allele
behavior/neurological
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• shorter mean latency to fall in the first trial and performance improves only slightly over subsequent trials
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nervous system
|
N |
• do not display defects in cerebellar development
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• at P70, but not at P20, Purkinje cells show a decrease in firing frequency
• at P70 Purkinje cells show an increase in variability of firing
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbfox1tm1.1Dblk mutation
(1 available);
any
Rbfox1 mutation
(33 available)
Tg(Nes-cre)1Kln mutation
(4 available)
|
|
|
mortality/aging
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|
• in mice treated with kainic acid
|
nervous system
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|
• increased incidence resulting in death in response to kainic acid treatment
|
behavior/neurological
|
|
• increased incidence resulting in death in response to kainic acid treatment
|
homeostasis/metabolism
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbfox1tm1.1Dblk mutation
(1 available);
any
Rbfox1 mutation
(33 available)
Tg(Nes-cre)1Kln mutation
(4 available)
|
|
|
mortality/aging
|
|
• in mice treated with kainic acid
|
reproductive system
nervous system
|
N |
• mice exhibit normal gross brain morphology
|
|
|
• infrequent spontaneous seizures
|
|
|
• increased incidence and duration of tonic-clonic seizures resulting in death in response to kainic acid treatment
|
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|
• in mice treated with kainic acid
|
|
|
• very modest decrease in spine density in the dentate gyrus
|
|
|
• mice require lower stimulus intensities to evoke field excitatory postsynaptic potentials compared with control mice
|
growth/size/body
behavior/neurological
|
|
• infrequent spontaneous seizures
|
|
|
• increased incidence and duration of tonic-clonic seizures resulting in death in response to kainic acid treatment
|
|
|
• in mice treated with kainic acid
|
homeostasis/metabolism
mortality/aging
|
|
• euthanasia due to immobility by 3?4 weeks of age
|
nervous system
|
|
• Purkinje cells show a marked decrease in firing frequency
|
behavior/neurological
|
|
• develop severe ataxia by 2 weeks of age becoming immobile by 3-4 weeks of age
|
growth/size/body
Analysis Tools