All Phenotypes Psmg1<tm1.1Smta> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Psmg1^tm1.1Smta
targeted mutation 1.1, Shigeo Murata
MGI:4820728

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psmg1^tm1.1Smta/Psmg1^tm1.1Smta	B6.Cg-Psmg1^tm1.1Smta	MGI:4820734
cn2	Psmg1^tm1.1Smta/Psmg1^tm1.1Smta Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * CBA * DBA	MGI:4820736
cn3	Psmg1^tm1.1Smta/Psmg1^tm1.1Smta Tg(Nes-cre)1Kln/0	involves: C57BL/6 * CBA * SJL	MGI:4820735

Allelic Composition	Psmg1^tm1.1Smta/Psmg1^tm1.1Smta
Genetic Background	B6.Cg-Psmg1^tm1.1Smta

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmg1^tm1.1Smta mutation (1 available); any Psmg1 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:162790 )

• mice are healthy and fertile

Allelic Composition	Psmg1^tm1.1Smta/Psmg1^tm1.1Smta Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: C57BL/6 * CBA * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmg1^tm1.1Smta mutation (1 available); any Psmg1 mutation (20 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:162790 )

N	• mortality is normal through 18 months

liver/biliary system

abnormal liver sinusoid morphology ( J:162790 )

• narrow sinusoids

abnormal hepatic cord morphology ( J:162790 )

• irregular hepatic cords

abnormal hepatocyte morphology ( J:162790 )

• mice exhibit enlarged hepatocytes with irregular hepatic cords and narrow sinusoids compared to in wild-type mice

• hepatocytes exhibit aberrant proliferation of the peroxisomes compared with wild-type cells

abnormal hepatocyte physiology ( J:162790 )

• hepatocytes undergo premature senescence compared with wild-type cells

cardiovascular system

abnormal liver sinusoid morphology ( J:162790 )

• narrow sinusoids

Allelic Composition	Psmg1^tm1.1Smta/Psmg1^tm1.1Smta Tg(Nes-cre)1Kln/0
Genetic Background	involves: C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmg1^tm1.1Smta mutation (1 available); any Psmg1 mutation (20 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:162790 )

• mice die by P21

nervous system

decreased cerebellar granule cell precursor proliferation ( J:162790 )

abnormal cerebral hemisphere morphology ( J:162790 )

• as early as P3, cerebrum weight is decreased compared to in wild-type mice

• however, the formation of pyramidal cell and granular cell layers is normal

decreased dentate gyrus size ( J:162790 )

• reduced

small hippocampus ( J:162790 )

thin cerebral cortex ( J:162790 )

abnormal cerebellum morphology ( J:162790 )

• as early as P3, cerebellum weight is decreased compared to in wild-type mice

abnormal cerebellum development ( J:162790 )

• mice lack the normal three layers observed in wild-type mice

behavior/neurological

limb grasping ( J:162790 )

tremors ( J:162790 )

ataxia ( J:162790 )

growth/size/body

postnatal growth retardation ( J:162790 )

cellular

decreased cerebellar granule cell precursor proliferation ( J:162790 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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