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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srpk2tm1Nik
targeted mutation 1, Nigel Killeen
MGI:4460670
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lrrc17tm1Nik/Lrrc17+
Nf1tm1Par/Nf1tm1Par
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4460776
cn2
 		Krastm4Tyj/Kras+
Lrrc17tm1Nik/Lrrc17+
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA MGI:4460775
cn3
 		Lrrc17tm1Nik/Lrrc17+
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA MGI:4460774
cx4
 		Lrrc17tm1Nik/Lrrc17tm1Nik
Srpk2tm1Nik/Srpk2tm1Nik 		involves: 129P2/OlaHsd * C57BL/6 MGI:4460773


Genotype
MGI:4460776
cn1
Allelic
Composition		 Lrrc17tm1Nik/Lrrc17+
Nf1tm1Par/Nf1tm1Par
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc17tm1Nik mutation (0 available); any Lrrc17 mutation (19 available)
Nf1tm1Par mutation (4 available); any Nf1 mutation (157 available)
Srpk2tm1Nik mutation (0 available); any Srpk2 mutation (45 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:161558 )
• in pIpC-treated mice with the same timing as in pIpC-treated Nf1tm1Par/Nf1tm1Par Tg(Mx1-cre)1Cgn mice

immune system
increased leukocyte cell number ( J:161558 )
• pIpC-treated mice develop myeloproliferative disorder with anemia unlike wild-type mice that is similar to in pIpC-treated Nf1tm1Par/Nf1tm1Par Tg(Mx1-cre)1Cgn mice

hematopoietic system
increased leukocyte cell number ( J:161558 )
• pIpC-treated mice develop myeloproliferative disorder with anemia unlike wild-type mice that is similar to in pIpC-treated Nf1tm1Par/Nf1tm1Par Tg(Mx1-cre)1Cgn mice




Genotype
MGI:4460775
cn2
Allelic
Composition		 Krastm4Tyj/Kras+
Lrrc17tm1Nik/Lrrc17+
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Lrrc17tm1Nik mutation (0 available); any Lrrc17 mutation (19 available)
Srpk2tm1Nik mutation (0 available); any Srpk2 mutation (45 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:161558 )
• in pIpC-treated mice similar to in pIpC-treated Krastm4Tyj Tg(Mx1-cre)1Cgn mice

immune system
increased leukocyte cell number ( J:161558 )
• pIpC-treated mice develop myeloproliferative disorder with anemia unlike wild-type mice that is similar to in pIpC-treated Krastm4Tyj Tg(Mx1-cre)1Cgn mice

hematopoietic system
abnormal blood cell morphology/development ( J:161558 )
• bone marrow cells from pIpC-treated mice spontaneous form colony forming units-granulocyte and macrophage (CFU-GM) in the absence of cytokines unlike wild-type cells
anemia ( J:161558 )
• in pIpC-treated mice similar to in pIpC-treated Krastm4Tyj Tg(Mx1-cre)1Cgn mice
increased leukocyte cell number ( J:161558 )
• pIpC-treated mice develop myeloproliferative disorder with anemia unlike wild-type mice that is similar to in pIpC-treated Krastm4Tyj Tg(Mx1-cre)1Cgn mice




Genotype
MGI:4460774
cn3
Allelic
Composition		 Lrrc17tm1Nik/Lrrc17+
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc17tm1Nik mutation (0 available); any Lrrc17 mutation (19 available)
Srpk2tm1Nik mutation (0 available); any Srpk2 mutation (45 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:161558 )
N
• mice exhibit a normal lifespan and causes of death

neoplasm
neoplasm ( J:161558 )
N
• MOL4070LTR-induced leukemia is the same as in similarly treated wild-type mice

hematopoietic system
hematopoietic system phenotype ( J:161558 )
N
• mice exhibit normal blood counts




Genotype
MGI:4460773
cx4
Allelic
Composition		 Lrrc17tm1Nik/Lrrc17tm1Nik
Srpk2tm1Nik/Srpk2tm1Nik
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc17tm1Nik mutation (0 available); any Lrrc17 mutation (19 available)
Srpk2tm1Nik mutation (0 available); any Srpk2 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:161558 )
• mice are normal and fertile




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory