Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6ratm1.1Drew mutation
(1 available);
any
Il6ra mutation
(35 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6ratm1.1Drew mutation
(1 available);
any
Il6ra mutation
(35 available)
Tg(GFAP-cre)8Gtm mutation
(1 available)
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mortality/aging
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• fewer than expected mice are present at weaning with only a few mice dying after birth
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behavior/neurological
N |
• mice exhibit normal vertical exploratory activity (rearings)
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• in the hole-board test, mice exhibit increased number of unexplored squares and a tendency for defecation compared with control mice
• mice exhibit decreased time in the center of a plus maze compared with control mice
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• in the hole-board test, mice exhibit increased number of head dips but not time spent dipping their head compared with control mice
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nervous system
N |
• mice exhibit normal levels of gliosis
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immune system
N |
• mice exhibit normal acute-phase response to turpentine challenge
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6ratm1.1Drew mutation
(1 available);
any
Il6ra mutation
(35 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation
(6 available);
any
Speer6-ps1 mutation
(4 available)
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immune system
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• acute-phase response to turpentine challenge is completely muted compared to in similarly treated wild-type mice
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homeostasis/metabolism