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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nr4a2tm1.1Pcn
targeted mutation 1.1, Pierre Chambon
MGI:4437024
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn Not Specified MGI:4437055
cn2
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
involves: 129S1/Sv * 129X1/SvJ MGI:4437054
cn3
Nr4a2tm1.1Pcn/Nr4a2+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ MGI:5547375
cn4
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
involves: 129S1/Sv * 129X1/SvJ MGI:5547376
cn5
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: C57BL/6 * C57BL/6NTac MGI:5547377
cn6
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Tg(Lck-cre)1Jtak/0
Not Specified MGI:5547378


Genotype
MGI:4437055
cn1
Allelic
Composition
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a2tm1.1Pcn mutation (0 available); any Nr4a2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• injection of adenovirus expressing cre do not alter brain morphology, expression of midbrain dopamine neuron markers, or microglia activation
• in the dorsolateral striatum and areas innervated by scattered ventral tegmental area of mice injected with an adenovirus expressing cre
• mice injected with an adenovirus expressing cre exhibit a progressive decrease in dopaminergic neurons compared with wild-type mice

behavior/neurological
• 3 to 4 months after injection with an adenovirus expressing cre, mice exhibit impaired performance in a stepping test compared with wild-type mice

homeostasis/metabolism
• in the dorsolateral striatum and areas innervated by scattered ventral tegmental area of mice injected with an adenovirus expressing cre




Genotype
MGI:4437054
cn2
Allelic
Composition
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a2tm1.1Pcn mutation (0 available); any Nr4a2 mutation (18 available)
Slc6a3tm1(cre)Lrsn mutation (0 available); any Slc6a3 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice do not survive beyond 3 weeks
• however, leaving pups with mothers improves perinatal survival beyond 3 weeks

nervous system
• at P1, striatal dopamine levels are decreased to 14% of wild-type
• at P14, the ratio of homovanillic acid (HVA) to dopamine is increased indicating increased dopamine turnover compared to in wild-type mice
• at P60, striatal dopamine levels are almost completely lost unlike in wild-type mice
• at P60, dopamine levels are more severely decreased in the caudate putamen compared to in the nucleus accumbens
• expression of midbrain dopamine neuron markers is lost compared to in wild-type mice
• mice exhibit a rapid loss of substantia nigra pars compacta cell bodies with only scattered ventral tegmental area neurons remaining compared with wild-type mice

behavior/neurological
• at 4 and 14 months
• L-DOPA-treated mice exhibit hyperactivity unlike similarly treated wild-type mice
• L-DOPA-treated mice exhibit repetitive behaviors (including repetitive gnawing, excessive grooming, and self-injury) unlike similarly treated wild-type mice

homeostasis/metabolism
• at P1, striatal dopamine levels are decreased to 14% of wild-type
• at P14, the ratio of homovanillic acid (HVA) to dopamine is increased indicating increased dopamine turnover compared to in wild-type mice
• at P60, striatal dopamine levels are almost completely lost unlike in wild-type mice
• at P60, dopamine levels are more severely decreased in the caudate putamen compared to in the nucleus accumbens
• serotonin levels in the caudate putamen and nucleus accumbens are increased compared to in wild-type mice
• L-DOPA-treated mice exhibit hyperactivity and repetitive behaviors unlike similarly treated wild-type mice

growth/size/body
• at 2 months, mice left with their mothers after weaning are 40% smaller than wild-type mice




Genotype
MGI:5547375
cn3
Allelic
Composition
Nr4a2tm1.1Pcn/Nr4a2+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (1 available); any Foxp3 mutation (32 available)
Nr4a2tm1.1Pcn mutation (0 available); any Nr4a2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Treg cells are not properly maintained

hematopoietic system
• Treg cells are not properly maintained




Genotype
MGI:5547376
cn4
Allelic
Composition
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (1 available); any Foxp3 mutation (32 available)
Nr4a2tm1.1Pcn mutation (0 available); any Nr4a2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• regulatory T cells are not properly maintained
• slightly attenuated suppressive activity
• in a transfer model of colitis, regulatory T cells fail to inhibit wasting disease and colitis compared with wild-type cells

hematopoietic system
• regulatory T cells are not properly maintained
• slightly attenuated suppressive activity
• in a transfer model of colitis, regulatory T cells fail to inhibit wasting disease and colitis compared with wild-type cells




Genotype
MGI:5547377
cn5
Allelic
Composition
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background
involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (343 available)
Nr4a2tm1.1Pcn mutation (0 available); any Nr4a2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions following tamoxifen-treatment
• reduced under Th17-skewing conditions following tamoxifen-treatment
• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions following tamoxifen-treatment

hematopoietic system
• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions following tamoxifen-treatment
• reduced under Th17-skewing conditions following tamoxifen-treatment
• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions following tamoxifen-treatment




Genotype
MGI:5547378
cn6
Allelic
Composition
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Tg(Lck-cre)1Jtak/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a2tm1.1Pcn mutation (0 available); any Nr4a2 mutation (18 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

immune system
N
• surviving mice exhibit no auto-immune disease symptoms up to 4 months of age
• mice exhibit normal numbers of regulatory T cells in the thymus and spleen
• DSS-treated mice exhibit accelerated body weight loss, severe intestinal inflammation, increased Th1 cells and attenuated increase of regulatory T cells in the colon and cecum lamina propria compared with control mice
• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions
• reduced under Th17-skewing conditions
• CD44highCD62Llow-activated and IFN-gamma CD4+ T cells
• in DSS-treated mice
• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions
• in DSS-treated mice

digestive/alimentary system
• DSS-treated mice exhibit accelerated body weight loss, severe intestinal inflammation, increased Th1 cells and attenuated increase of regulatory T cells in the colon and cecum lamina propria compared with control mice

growth/size/body
• accelerated in DSS-treated mice

hematopoietic system
• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions
• reduced under Th17-skewing conditions
• CD44highCD62Llow-activated and IFN-gamma CD4+ T cells
• in DSS-treated mice
• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions
• in DSS-treated mice





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory