Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a2tm1.1Pcn mutation
(0 available);
any
Nr4a2 mutation
(40 available)
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nervous system
N |
• injection of adenovirus expressing cre do not alter brain morphology, expression of midbrain dopamine neuron markers, or microglia activation
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• mice injected with an adenovirus expressing cre exhibit a progressive decrease in dopaminergic neurons compared with wild-type mice
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behavior/neurological
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• 3 to 4 months after injection with an adenovirus expressing cre, mice exhibit impaired performance in a stepping test compared with wild-type mice
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a2tm1.1Pcn mutation
(0 available);
any
Nr4a2 mutation
(40 available)
Slc6a3tm1(cre)Lrsn mutation
(1 available);
any
Slc6a3 mutation
(66 available)
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mortality/aging
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• mice do not survive beyond 3 weeks
• however, leaving pups with mothers improves perinatal survival beyond 3 weeks
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nervous system
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• expression of midbrain dopamine neuron markers is lost compared to in wild-type mice
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• mice exhibit a rapid loss of substantia nigra pars compacta cell bodies with only scattered ventral tegmental area neurons remaining compared with wild-type mice
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behavior/neurological
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• L-DOPA-treated mice exhibit hyperactivity unlike similarly treated wild-type mice
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• L-DOPA-treated mice exhibit repetitive behaviors (including repetitive gnawing, excessive grooming, and self-injury) unlike similarly treated wild-type mice
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homeostasis/metabolism
growth/size/body
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• at 2 months, mice left with their mothers after weaning are 40% smaller than wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation
(2 available);
any
Foxp3 mutation
(55 available)
Nr4a2tm1.1Pcn mutation
(0 available);
any
Nr4a2 mutation
(40 available)
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immune system
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• Treg cells are not properly maintained
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hematopoietic system
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• Treg cells are not properly maintained
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation
(2 available);
any
Foxp3 mutation
(55 available)
Nr4a2tm1.1Pcn mutation
(0 available);
any
Nr4a2 mutation
(40 available)
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immune system
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• regulatory T cells are not properly maintained
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• slightly attenuated suppressive activity
• in a transfer model of colitis, regulatory T cells fail to inhibit wasting disease and colitis compared with wild-type cells
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hematopoietic system
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• regulatory T cells are not properly maintained
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• slightly attenuated suppressive activity
• in a transfer model of colitis, regulatory T cells fail to inhibit wasting disease and colitis compared with wild-type cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation
(2 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Nr4a2tm1.1Pcn mutation
(0 available);
any
Nr4a2 mutation
(40 available)
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immune system
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• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions following tamoxifen-treatment
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• reduced under Th17-skewing conditions following tamoxifen-treatment
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• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions following tamoxifen-treatment
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hematopoietic system
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• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions following tamoxifen-treatment
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• reduced under Th17-skewing conditions following tamoxifen-treatment
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• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions following tamoxifen-treatment
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a2tm1.1Pcn mutation
(0 available);
any
Nr4a2 mutation
(40 available)
Tg(Lck-cre)1Jtak mutation
(3 available)
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mortality/aging
immune system
N |
• surviving mice exhibit no auto-immune disease symptoms up to 4 months of age
• mice exhibit normal numbers of regulatory T cells in the thymus and spleen
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• DSS-treated mice exhibit accelerated body weight loss, severe intestinal inflammation, increased Th1 cells and attenuated increase of regulatory T cells in the colon and cecum lamina propria compared with control mice
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• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions
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• reduced under Th17-skewing conditions
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• CD44highCD62Llow-activated and IFN-gamma CD4+ T cells
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• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions
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digestive/alimentary system
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• DSS-treated mice exhibit accelerated body weight loss, severe intestinal inflammation, increased Th1 cells and attenuated increase of regulatory T cells in the colon and cecum lamina propria compared with control mice
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growth/size/body
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• accelerated in DSS-treated mice
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hematopoietic system
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• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions
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• reduced under Th17-skewing conditions
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• CD44highCD62Llow-activated and IFN-gamma CD4+ T cells
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• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions
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