Mouse Genome Informatics
cn1
    Nr4a2tm1.1Ich/Nr4a2tm1.1Ich
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• injection of adenovirus expressing cre do not alter brain morphology, expression of midbrain dopamine neuron markers, or microglia activation (J:157098)
• in the dorsolateral striatum and areas innervated by scattered ventral tegmental area of mice injected with an adenovirus expressing cre
• mice injected with an adenovirus expressing cre exhibit a progressive decrease in dopaminergic neurons compared with wild-type mice

behavior/neurological
• 3 to 4 months after injection with an adenovirus expressing cre, mice exhibit impaired performance in a stepping test compared with wild-type mice

homeostasis/metabolism
• in the dorsolateral striatum and areas innervated by scattered ventral tegmental area of mice injected with an adenovirus expressing cre


Mouse Genome Informatics
cn2
    Nr4a2tm1.1Ich/Nr4a2tm1.1Ich
Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice do not survive beyond 3 weeks
• however, leaving pups with mothers improves perinatal survival beyond 3 weeks

nervous system
• at P1, striatal dopamine levels are decreased to 14% of wild-type
• at P14, the ratio of homovanillic acid (HVA) to dopamine is increased indicating increased dopamine turnover compared to in wild-type mice
• at P60, striatal dopamine levels are almost completely lost unlike in wild-type mice
• at P60, dopamine levels are more severely decreased in the caudate putamen compared to in the nucleus accumbens
• expression of midbrain dopamine neuron markers is lost compared to in wild-type mice
• mice exhibit a rapid loss of substantia nigra pars compacta cell bodies with only scattered ventral tegmental area neurons remaining compared with wild-type mice

behavior/neurological
• at 4 and 14 months
• L-DOPA-treated mice exhibit hyperactivity unlike similarly treated wild-type mice
• L-DOPA-treated mice exhibit repetitive behaviors (including repetitive gnawing, excessive grooming, and self-injury) unlike similarly treated wild-type mice

homeostasis/metabolism
• at P1, striatal dopamine levels are decreased to 14% of wild-type
• at P14, the ratio of homovanillic acid (HVA) to dopamine is increased indicating increased dopamine turnover compared to in wild-type mice
• at P60, striatal dopamine levels are almost completely lost unlike in wild-type mice
• at P60, dopamine levels are more severely decreased in the caudate putamen compared to in the nucleus accumbens
• serotonin levels in the caudate putamen and nucleus accumbens are increased compared to in wild-type mice
• L-DOPA-treated mice exhibit hyperactivity and repetitive behaviors unlike similarly treated wild-type mice

growth/size
• at 2 months, mice left with their mothers after weaning are 40% smaller than wild-type mice


Mouse Genome Informatics
cn3
    Nr4a2tm1.1Ich/Nr4a2+
Foxp3tm4(YFP/cre)Ayr/Foxp3+

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• Treg cells are not properly maintained (J:205658)

hematopoietic system
• Treg cells are not properly maintained (J:205658)


Mouse Genome Informatics
cn4
    Foxp3tm4(YFP/cre)Ayr/Foxp3+
Nr4a2tm1.1Ich/Nr4a2tm1.1Ich

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• regulatory T cells are not properly maintained (J:205658)
• slightly attenuated suppressive activity (J:205658)
• in a transfer model of colitis, regulatory T cells fail to inhibit wasting disease and colitis compared with wild-type cells (J:205658)

hematopoietic system
• regulatory T cells are not properly maintained (J:205658)
• slightly attenuated suppressive activity (J:205658)
• in a transfer model of colitis, regulatory T cells fail to inhibit wasting disease and colitis compared with wild-type cells (J:205658)


Mouse Genome Informatics
cn5
    Nr4a2tm1.1Ich/Nr4a2tm1.1Ich
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+

involves: C57BL/6 * C57BL/6NTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions following tamoxifen-treatment
• reduced under Th17-skewing conditions following tamoxifen-treatment
• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions following tamoxifen-treatment

hematopoietic system
• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions following tamoxifen-treatment
• reduced under Th17-skewing conditions following tamoxifen-treatment
• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions following tamoxifen-treatment


Mouse Genome Informatics
cn6
    Nr4a2tm1.1Ich/Nr4a2tm1.1Ich
Tg(Lck-cre)1Jtak/0

Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• more than half of mice

immune system
N
• surviving mice exhibit no auto-immune disease symptoms up to 4 months of age (J:205658)
• mice exhibit normal numbers of regulatory T cells in the thymus and spleen (J:205658)
• DSS-treated mice exhibit accelerated body weight loss, severe intestinal inflammation, increased Th1 cells and attenuated increase of regulatory T cells in the colon and cecum lamina propria compared with control mice
• CD44highCD62Llow-activated and IFN-gamma CD4+ T cells
• in DSS-treated mice
• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions
• reduced under Th17-skewing conditions
• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions
• in DSS-treated mice

digestive/alimentary system
• DSS-treated mice exhibit accelerated body weight loss, severe intestinal inflammation, increased Th1 cells and attenuated increase of regulatory T cells in the colon and cecum lamina propria compared with control mice

growth/size
• accelerated in DSS-treated mice

hematopoietic system
• CD44highCD62Llow-activated and IFN-gamma CD4+ T cells
• in DSS-treated mice
• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions
• reduced under Th17-skewing conditions
• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions
• in DSS-treated mice