Phenotypes associated with this allele
immune system
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• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
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• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
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• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
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• decrease in the numbers of adoptively transferred transgenic CD8+ T cells compared to controls by 30 days after immunization
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hematopoietic system
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• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
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• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
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• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
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hematopoietic system
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• increase in immature CD11b+ CXCR3+ NK cells in spleen and bone marrow
• more mature KLRG-1+ CD11b+ NK cells are underrepresented in spleen and bone marrow
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• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
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• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
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• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
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• decrease in proliferation of CD27+ CD11b+ cells
• decrease in activation of adoptively transferred wild-type NK cells in response to lipopolysaccaride
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immune system
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• increase in immature CD11b+ CXCR3+ NK cells in spleen and bone marrow
• more mature KLRG-1+ CD11b+ NK cells are underrepresented in spleen and bone marrow
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• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
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• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
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• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
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• exaggerated contraction of adoptively transferred transgenic CD8+ T cells seen as early as 10 days after immunization
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• decrease in proliferation of CD27+ CD11b+ cells
• decrease in activation of adoptively transferred wild-type NK cells in response to lipopolysaccaride
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hematopoietic system
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• increase in immature CD11b+ CXCR3+ NK cells in spleen and bone marrow
• more mature KLRG-1+ CD11b+ NK cells are underrepresented in spleen and bone marrow
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• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
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• marked decrease in the ratio of CD62Lhi to CD62Llo memory phenotype CD8+ T cells
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• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• marked decrease in the number of CD62Lhi memory phenotype CD8+ T cells
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• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• marked decrease in the number of CD62Lhi memory phenotype CD8+ T cells
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• decrease in proliferation of CD27+ CD11b+ cells
• decrease in activation of adoptively transferred wild-type NK cells in response to lipopolysaccaride
|
immune system
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• increase in immature CD11b+ CXCR3+ NK cells in spleen and bone marrow
• more mature KLRG-1+ CD11b+ NK cells are underrepresented in spleen and bone marrow
|
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• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
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• marked decrease in the ratio of CD62Lhi to CD62Llo memory phenotype CD8+ T cells
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• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• marked decrease in the number of CD62Lhi memory phenotype CD8+ T cells
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• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• marked decrease in the number of CD62Lhi memory phenotype CD8+ T cells
|
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• decrease in proliferation of CD27+ CD11b+ cells
• decrease in activation of adoptively transferred wild-type NK cells in response to lipopolysaccaride
|
hematopoietic system
immune system