All Phenotypes Syk<tm1.2Tara> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Syk^tm1.2Tara
targeted mutation 1.2, Alexander Tarakhovsky
MGI:4415245

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Syk^tm1.2Tara/Syk^tm1.2Tara Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd	MGI:5568508
cn2	Itgam^tm1Myd/Itgam^tm1Myd Syk^tm1Tyb/Syk^tm1.2Tara Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:4415250
cn3	Syk^tm1Tyb/Syk^tm1.2Tara Tg(S100A8-cre,-EGFP)1Ilw/0	involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6	MGI:4415251
cn4	Syk^tm1Tyb/Syk^tm1.2Tara Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:4415249
cn5	Syk^tm1.2Tara/Syk^tm1.2Tara Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5314240

Allelic Composition	Syk^tm1.2Tara/Syk^tm1.2Tara Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syk^tm1.2Tara mutation (1 available); any Syk mutation (42 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell morphology ( J:208904 )

• mature B cells exhibit a follicular B cell-like phenotype

immune system

abnormal B cell morphology ( J:208904 )

• mature B cells exhibit a follicular B cell-like phenotype

Allelic Composition	Itgam^tm1Myd/Itgam^tm1Myd Syk^tm1Tyb/Syk^tm1.2Tara Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgam^tm1Myd mutation (1 available); any Itgam mutation (47 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Syk^tm1.2Tara mutation (1 available); any Syk mutation (42 available)
Syk^tm1Tyb mutation (0 available); any Syk mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit an increased in viable S. aureus compared to in similarly treated wild-type mice

hematopoietic system

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit an increased in viable S. aureus compared to in similarly treated wild-type mice

Allelic Composition	Syk^tm1Tyb/Syk^tm1.2Tara Tg(S100A8-cre,-EGFP)1Ilw/0
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syk^tm1.2Tara mutation (1 available); any Syk mutation (42 available)
Syk^tm1Tyb mutation (0 available); any Syk mutation (42 available)
Tg(S100A8-cre,-EGFP)1Ilw mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit a 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice

hematopoietic system

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit a 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice

Allelic Composition	Syk^tm1Tyb/Syk^tm1.2Tara Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Syk^tm1.2Tara mutation (1 available); any Syk mutation (42 available)
Syk^tm1Tyb mutation (0 available); any Syk mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal neutrophil physiology ( J:155479 )

• migration of neutrophils to the cite of bacterial infection is enhanced compared to in similarly treated wild-type mice

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit a 3- to 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice

hematopoietic system

abnormal neutrophil physiology ( J:155479 )

• migration of neutrophils to the cite of bacterial infection is enhanced compared to in similarly treated wild-type mice

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit a 3- to 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice

Allelic Composition	Syk^tm1.2Tara/Syk^tm1.2Tara Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syk^tm1.2Tara mutation (1 available); any Syk mutation (42 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:181715 )

N	• mice exhibit normal perinatal survival

immune system

immune system phenotype ( J:181715 )

N	• mice exhibit normal lymphatic vessels

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:181715 )

N	• mice do not exhibit edema

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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