Tg(S100A8-cre,-EGFP)1Ilw
Transgene Detail
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Symbol: |
Tg(S100A8-cre,-EGFP)1Ilw |
Name: |
transgene insertion 1, Irving L Weissman |
MGI ID: |
MGI:4415239 |
Synonyms: |
MRP8-Cre-ires/GFP, Mrp8creTg, Tg(S100A8-cre,-GFP)1Empa, Tg(S100A8-cre,-GFP)1Ilw |
Transgene: |
Tg(S100A8-cre,-EGFP)1Ilw Location: unknown Genetic Position: Chr5, Syntenic
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Alliance: |
Tg(S100A8-cre,-EGFP)1Ilw page
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Transgene Type: |
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Transgenic (Recombinase) |
Mutations: |
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Insertion, Intergenic deletion
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Tg(S100A8-cre,-EGFP)1Ilw involves 2 genes/genome features (Ap1s1, Serpine1)
View all
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Tg(S100A8-cre,-EGFP)1Ilw expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Homolog in Mouse |
Note |
human |
S100A8 (6279) |
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Mutation details: The human promoter drives expression of cre followed by an IRES sequence and EGFP in granulocytes and a fraction of myelomonocytic progenitors. Two founders were generated (no line information given). a A single copy of the transgene integrated at a single site on chromosome 5 (137,042,580-137,086,690; mouse mm10). This insertion leads to a 44 kb deletion of the host genome, resulting in complete deletion of the Serpine1 gene and partial deletion of the Ap1s1 gene.
(J:94778, J:323640)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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S100A8
(human)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:94778 Passegue E, et al., JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell. 2004 Oct 29;119(3):431-43 |
All: |
94 reference(s) |
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