Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
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neoplasm
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• 1 out of 15 mice develop a mammary tumor over a period of 18-24 months
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endocrine/exocrine glands
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• 1 out of 15 mice develop a mammary tumor over a period of 18-24 months
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immune system
N |
• no immunological defects
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integument
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• 1 out of 15 mice develop a mammary tumor over a period of 18-24 months
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk3tm1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
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liver/biliary system
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• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration
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• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion
• a prominent increase in liver size as early as 3 days after Adeno-Cre administration
• 2-fold larger at 8 days and 4-fold larger by 3 months
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• with a mean latency of 10 weeks after Adeno-Cre injection
• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes
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neoplasm
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• with a mean latency of 10 weeks after Adeno-Cre injection
• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes
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cellular
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• resistance to Fas-Induced Apoptosis in the liver as determined by histological examination, TUNEL staining and western blotting for cleaved caspase-3
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• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration
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growth/size/body
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• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion
• a prominent increase in liver size as early as 3 days after Adeno-Cre administration
• 2-fold larger at 8 days and 4-fold larger by 3 months
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk4tm1Kina mutation
(0 available);
any
Stk4 mutation
(72 available)
Tg(Nkx2-1-cre)2Sand mutation
(2 available)
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mortality/aging
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• a markedly sick appearance at birth and almost all mice died within the first 15 d after birt
• born at normal Mendelian ratio
• lung size and dry lung weight were comparable between Mst1/2 dKO mice and control mice at E15.5 and E18.5
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respiratory system
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• at E18.5, lungs showed a markedly increased number of proliferative cells and mildly diminished cell death
• no abnormal proliferation of mesenchymal cells
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• displayed spontaneous infiltration of inflammatory cells
• No bacteria and fungi were detected in lung sections or in cytospins of bronchoalveolar lavage fluid, ruling out the possibility of infection
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• Lung Epithelial Cells Causes Abnormal Lung Maturation: Impaired Surfactant Homeostasis and Delayed Differentiation of Type I and II Pneumocytes
• vascularization was normal
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• reduced aerated space compacted with immature-looking cuboidal cells
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• lung showed severe accumulation of inflammatory cells in the alveolar space and bronchiole with multiple atelectasis and emphysematous lesions
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• lung showed severe accumulation of inflammatory cells in the alveolar space and bronchiole with multiple atelectasis and emphysematous lesions
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• at around post natal day 5
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immune system
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• displayed spontaneous infiltration of inflammatory cells
• No bacteria and fungi were detected in lung sections or in cytospins of bronchoalveolar lavage fluid, ruling out the possibility of infection
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cellular
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• at E18.5, lungs showed a markedly increased number of proliferative cells and mildly diminished cell death
• no abnormal proliferation of mesenchymal cells
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
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mortality/aging
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• none survive beyond E9.5
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embryo
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• under-vascularized yolk sacs at E9.5
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• failure to turn by E9.5
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• first signs of retardation evident at embryonic day 8.5 (E8.5)
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• E8.5 embryos are smaller
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• failure to close the neural tube by E9.5
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growth/size/body
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• first signs of retardation evident at embryonic day 8.5 (E8.5)
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• E8.5 embryos are smaller
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nervous system
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• failure to close the neural tube by E9.5
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cardiovascular system
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• under-vascularized yolk sacs at E9.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
|
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behavior/neurological
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• starting at 7 months of age
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neoplasm
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• highly aggressive hepatocellular carcinomas (HCCs)
• HCCs in 6 out of 7 asymptomatic mice at 7 months old
• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles
• mice that show morbidity (13 out of 16 by 15 months old) harbor liver tumors
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liver/biliary system
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• some mice display overgrowth (2- to 4-fold) of the apparently normal liver tissue
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• highly aggressive hepatocellular carcinomas (HCCs)
• HCCs in 6 out of 7 asymptomatic mice at 7 months old
• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles
• mice that show morbidity (13 out of 16 by 15 months old) harbor liver tumors
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growth/size/body
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• some mice display overgrowth (2- to 4-fold) of the apparently normal liver tissue
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
|
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neoplasm
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• highly aggressive hepatocellular carcinomas (HCCs)
• HCCs in 3 out of 12 mice by 15 months of age
• no mice (n = 6) have visible tumors among 7-month-old asymptomatic animals
• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles
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liver/biliary system
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• highly aggressive hepatocellular carcinomas (HCCs)
• HCCs in 3 out of 12 mice by 15 months of age
• no mice (n = 6) have visible tumors among 7-month-old asymptomatic animals
• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles
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