All Phenotypes Otx2<tm11Asim> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Otx2^tm11Asim
targeted mutation 11, Antonio Simeone
MGI:4365830

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx2^tm11Asim/Otx2^tm11Asim	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5573222
ht2	Otx2^tm11Asim/Otx2⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5573223
ht3	Otx2^tm9Asim/Otx2^tm11Asim	involves: 129P2/OlaHsd	MGI:4365908
ht4	Otx2^tm10Asim/Otx2^tm11Asim	involves: 129P2/OlaHsd	MGI:4365910
ht5	Otx2^tm12.1Asim/Otx2^tm11Asim	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5573224
cn6	Otx2^tm6Asim/Otx2^tm11Asim Slc6a3^{tm1.1(cre)Bkmn}/Slc6a3⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:4887467

Allelic Composition	Otx2^tm11Asim/Otx2^tm11Asim
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm11Asim mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:207121 )

• mice die at E9.5

Allelic Composition	Otx2^tm11Asim/Otx2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm11Asim mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:207121 )

N	• normal Mueller glia and amacrine cell numbers at P30

decreased retina cone cell number ( J:207121 )

• reduced red/green sensitive cones in most of the retina in mice older than P300

abnormal retina bipolar cell morphology ( J:207121 )

• reduced numbers at P30

abnormal retina horizontal cell morphology ( J:207121 )

• reduced numbers in the inner nuclear layer

thin retina inner nuclear layer ( J:207121 )

• at P14 and progressively worse at P30, P60 and P120

abnormal cone electrophysiology ( J:207121 )

• reduced photopic ERG amplitude at P30

abnormal rod electrophysiology ( J:207121 )

• reduced a-wave under scotopic conditions at P30 and P60

• increased a-wave and b-wave latency at P60 under scotopic conditions

• reduced b-wave under scotopic conditions at P30

decreased visual acuity ( J:207121 )

• mice exhibit reduced response in a visual acuity test

nervous system

decreased retina cone cell number ( J:207121 )

• reduced red/green sensitive cones in most of the retina in mice older than P300

abnormal retina bipolar cell morphology ( J:207121 )

• reduced numbers at P30

abnormal retina horizontal cell morphology ( J:207121 )

• reduced numbers in the inner nuclear layer

Allelic Composition	Otx2^tm9Asim/Otx2^tm11Asim
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm11Asim mutation (1 available); any Otx2 mutation (50 available)
Otx2^tm9Asim mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal forebrain development ( J:153562 )

• at E9.5, mice exhibit loss of forebrain markers

abnormal midbrain development ( J:153562 )

• at E9.5, mice exhibit loss of midbrain markers

growth/size/body

acephaly ( J:153562 )

• in almost all mice

Allelic Composition	Otx2^tm10Asim/Otx2^tm11Asim
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm10Asim mutation (1 available); any Otx2 mutation (50 available)
Otx2^tm11Asim mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:153562 )

• 70% of mice exhibit heavy abnormalities and reminiscent of Otx2 null embryos and 30% of mice exhibit less severe defects on the body and head

growth/size/body

abnormal head morphology ( J:153562 )

Allelic Composition	Otx2^tm12.1Asim/Otx2^tm11Asim
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm11Asim mutation (1 available); any Otx2 mutation (50 available)
Otx2^tm12.1Asim mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:207121 )

• mice die at birth

nervous system

forebrain hypoplasia ( J:207121 )

midbrain hypoplasia ( J:207121 )

growth/size/body

abnormal head morphology ( J:207121 )

• truncated

Allelic Composition	Otx2^tm6Asim/Otx2^tm11Asim Slc6a3^{tm1.1(cre)Bkmn}/Slc6a3⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm11Asim mutation (1 available); any Otx2 mutation (50 available)
Otx2^tm6Asim mutation (1 available); any Otx2 mutation (50 available)
Slc6a3^{tm1.1(cre)Bkmn} mutation (3 available); any Slc6a3 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased susceptibility to dopaminergic neuron neurotoxicity ( J:166896 )

• MPTP-treated mice exhibit reduced numbers of tyrosine hydroxylase (TH)+ neurons and GFP+ TH+ neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) compared with similarly treated wild-type mice

abnormal neuron differentiation ( J:166896 )

• the percentage of GFP+ glyco-Slc6a3 (DAT)+ neurons is higher than in control mice

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:166896 )

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:166896 )

abnormal neuron differentiation ( J:166896 )

• the percentage of GFP+ glyco-Slc6a3 (DAT)+ neurons is higher than in control mice

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