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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dpcd/PollGt(OST280355)Lex
gene trap OST280355, Lexicon Genetics
MGI:4262238
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dpcd/PollGt(OST280355)Lex/Dpcd/PollGt(OST280355)Lex involves: 129S5/SvEvBrd * C57BL/6Brd MGI:4950027


Genotype
MGI:4950027
hm1
Allelic
Composition
Dpcd/PollGt(OST280355)Lex/Dpcd/PollGt(OST280355)Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6Brd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dpcd/PollGt(OST280355)Lex mutation (0 available); any Dpcd mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• born in slightly reduced numbers

growth/size/body
• nasal passages and sinuses were often filled with abundant mucopurulent exudate
• smaller than controls (J:171184)
• displayed by 50% of homozygotes (J:171184)

nervous system
• hydrocephalus accompanied by histological lesions consistent with ciliary dysfunction
• moderate to marked (J:171184)
• moderate to marked (J:171184)

craniofacial
• in severely affected individuals who are also inactive (J:171184)
• when the domed skull is less prominent activity is more normal (J:171184)
• nasal passages and sinuses were often filled with abundant mucopurulent exudate

behavior/neurological
• severely affected individuals who display domed skulls are also inactive

reproductive system
(J:171184)
(J:185566)
• round sperm heads (J:171184)
(J:185566)
(J:171184)
• male infertility with apparently normal spermatogenesis (J:185566)
• immobile sperm (J:171184)
(J:185566)

respiratory system
• nasal passages and sinuses were often filled with abundant mucopurulent exudate
• severe nasal exudates (J:171184)
• nasal passages and sinuses were often filled with abundant mucopurulent exudate (J:185566)

skeleton
• in severely affected individuals who are also inactive (J:171184)
• when the domed skull is less prominent activity is more normal (J:171184)

hearing/vestibular/ear
• otitis media present in most animals

immune system
• otitis media present in most animals

cellular
(J:171184)
(J:185566)
• round sperm heads (J:171184)
(J:185566)





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory