Mouse Genome Informatics
hm1
    Dpcd/PollGt(OST280355)Lex/Dpcd/PollGt(OST280355)Lex
involves: 129S5/SvEvBrd * C57BL/6Brd-Tyrc-Brd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• born in slightly reduced numbers

growth/size
• nasal passages and sinuses were often filled with abundant mucopurulent exudate
• smaller than controls (J:171184)
• displayed by 50% of homozygotes (J:171184)

nervous system
• hydrocephalus accompanied by histological lesions consistent with ciliary dysfunction
• moderate to marked (J:171184)
• moderate to marked (J:171184)

craniofacial
• in severely affected individuals who are also inactive (J:171184)
• when the domed skull is less prominent activity is more normal (J:171184)
• nasal passages and sinuses were often filled with abundant mucopurulent exudate

behavior/neurological
• severely affected individuals who display domed skulls are also inactive

reproductive system
(J:171184)
(J:171184)
(J:185566)
• round sperm heads (J:171184)
(J:185566)
(J:171184)
• male infertility with apparently normal spermatogenesis (J:185566)
• immobile sperm (J:171184)
(J:185566)

respiratory system
• nasal passages and sinuses were often filled with abundant mucopurulent exudate
• severe nasal exudates (J:171184)
• nasal passages and sinuses were often filled with abundant mucopurulent exudate (J:185566)

skeleton
• in severely affected individuals who are also inactive (J:171184)
• when the domed skull is less prominent activity is more normal (J:171184)

hearing/vestibular/ear
• otitis media present in most animals

immune system
• otitis media present in most animals

cellular
(J:171184)
(J:185566)

Mouse Models of Human Disease
OMIM IDRef(s)
Ciliary Dyskinesia, Primary, 1; CILD1 244400 J:171184