All Phenotypes Nr0b2<tm1.1Mjev> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nr0b2^tm1.1Mjev
targeted mutation 1.1, Mark J Evans
MGI:3847927

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr0b2^tm1.1Mjev/Nr0b2^tm1.1Mjev	involves: 129S/SvEvBrd * 129S4/SvJae	MGI:3847956
cx2	Ldlr^tm1Her/Ldlr^tm1Her Nr0b2^tm1.1Mjev/Nr0b2^tm1.1Mjev	involves: 129S/SvEvBrd * 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3847958

Allelic Composition	Nr0b2^tm1.1Mjev/Nr0b2^tm1.1Mjev
Genetic Background	involves: 129S/SvEvBrd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr0b2^tm1.1Mjev mutation (0 available); any Nr0b2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:149005 )

N	• mice exhibit normal serum total cholesterol, triglyceride, alanine transaminase, and aspartate transaminase levels • mice are resistant to decreased cholesterol levels when fed a cholesterol diet with cholic acid

decreased circulating cholesterol level ( J:149005 )

• when fed an iodine-deficient diet compared to similarly treated wild-type mice

decreased circulating HDL cholesterol level ( J:149005 )

• when fed an iodine-deficient diet compared to similarly treated wild-type mice

decreased circulating LDL cholesterol level ( J:149005 )

• when fed a cholesterol with cholic acid diet compared to similarly treated wild-type mice

• when fed an iodine-deficient diet compared to similarly treated wild-type mice

decreased circulating VLDL cholesterol level ( J:149005 )

• when fed a cholesterol diet with cholic acid compared to similarly treated wild-type mice

Allelic Composition	Ldlr^tm1Her/Ldlr^tm1Her Nr0b2^tm1.1Mjev/Nr0b2^tm1.1Mjev
Genetic Background	involves: 129S/SvEvBrd * 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (76 available)
Nr0b2^tm1.1Mjev mutation (0 available); any Nr0b2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:149005 )

N	• mice fed a Western diet fail to exhibit an increase in triglyceride and VLDL cholesterol levels unlike wild-type mice

increased circulating HDL cholesterol level ( J:149005 )

• when fed a high fat diet

decreased circulating LDL cholesterol level ( J:149005 )

• mice fed a Western diet exhibit a reduced elevation in LDL cholesterol levels compared with similarly treated Ldlr^tm1Her homozygotes

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