Nr0b2^tm1.1Mjev
Targeted Allele Detail

Summary

• Symbol: Nr0b2^tm1.1Mjev
• Name: nuclear receptor subfamily 0, group B, member 2; targeted mutation 1.1, Mark J Evans
• MGI ID: MGI:3847927
• Synonyms: SHP^-
• Gene: Nr0b2 Location: Chr4:133280687-133283847 bp, + strand Genetic Position: Chr4, 66.25 cM
• Alliance: Nr0b2^tm1.1Mjev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149005
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Germ line, cre mediated recombination removed exon 1. The absence of transcript expression was confirmed by real-time PCR on liver and ileum extracts. (J:149005)

Generation of Nr0b2^tm1Mjev and Nr0b2^tm1.1Mjev alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr0b2 Mutation: 15 strains or lines available

References

• Original: J:149005 Hartman HB, et al., Loss of small heterodimer partner expression in the liver protects against dyslipidemia. J Lipid Res. 2009 Feb;50(2):193-203
• All: 3 reference(s)