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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Eef1a1tm1(Kras*)Arge
targeted mutation 1, Argiris Efstratiadis
MGI:3837679
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Eef1a1tm1(Kras*)Arge/Eef1a1+
Waptm1(cre)Arge/Wap+
involves: 129S1/Sv MGI:3837707
cn2
Eef1a1tm1(Kras*)Arge/Eef1a1+
Igf1rtm2Arge/Igf1r+
Waptm1(cre)Arge/Wap+
involves: 129S1/Sv MGI:3837708
cn3
Eef1a1tm1(Kras*)Arge/Eef1a1+
Igf1rtm2Arge/Igf1rtm2Arge
Waptm1(cre)Arge/Wap+
involves: 129S1/Sv MGI:3837711
cn4
Eef1a1tm1(Kras*)Arge/Eef1a1+
Tg(Hsp70-1-cre)1Arge/0
involves: 129S1/Sv * C57BL/6J * CBA MGI:3837706


Genotype
MGI:3837707
cn1
Allelic
Composition
Eef1a1tm1(Kras*)Arge/Eef1a1+
Waptm1(cre)Arge/Wap+
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm1(Kras*)Arge mutation (0 available); any Eef1a1 mutation (53 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice
• median tumor-free survival of lactating female mice is 9 days from the first parturition
• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas
• however, treatment with picropodophyllin decreases tumor mass

integument
• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice
• median tumor-free survival of lactating female mice is 9 days from the first parturition
• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas
• however, treatment with picropodophyllin decreases tumor mass

mortality/aging
• median tumor-free survival of lactating female mice is 9 days from the first parturition

neoplasm
• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice
• median tumor-free survival of lactating female mice is 9 days from the first parturition
• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas
• however, treatment with picropodophyllin decreases tumor mass

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
OMIM:600048
OMIM:605365
J:146290




Genotype
MGI:3837708
cn2
Allelic
Composition
Eef1a1tm1(Kras*)Arge/Eef1a1+
Igf1rtm2Arge/Igf1r+
Waptm1(cre)Arge/Wap+
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm1(Kras*)Arge mutation (0 available); any Eef1a1 mutation (53 available)
Igf1rtm2Arge mutation (1 available); any Igf1r mutation (49 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 43 days from the first parturition

endocrine/exocrine glands
• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 43 days from the first parturition

mortality/aging
• median tumor free survival of lactating females is 43 days from the first parturition

neoplasm
• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 43 days from the first parturition




Genotype
MGI:3837711
cn3
Allelic
Composition
Eef1a1tm1(Kras*)Arge/Eef1a1+
Igf1rtm2Arge/Igf1rtm2Arge
Waptm1(cre)Arge/Wap+
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm1(Kras*)Arge mutation (0 available); any Eef1a1 mutation (53 available)
Igf1rtm2Arge mutation (1 available); any Igf1r mutation (49 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 101 days from the first parturition

endocrine/exocrine glands
• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 101 days from the first parturition

mortality/aging
• median tumor free survival of lactating females is 101 days from the first parturition

neoplasm
• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1tm1(Kras*)Arge Waptm1(cre)Arge heterozygotes
• median tumor free survival of lactating females is 101 days from the first parturition




Genotype
MGI:3837706
cn4
Allelic
Composition
Eef1a1tm1(Kras*)Arge/Eef1a1+
Tg(Hsp70-1-cre)1Arge/0
Genetic
Background
involves: 129S1/Sv * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm1(Kras*)Arge mutation (0 available); any Eef1a1 mutation (53 available)
Tg(Hsp70-1-cre)1Arge mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory