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Allele Symbol Allele Name Allele ID |
Crktm1Cur targeted mutation 1, Tom Curran MGI:3830007 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice weigh 23% less than wild-type mice
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| N |
• mice exhibit normal cerebellum, hippocampus and cerebral cortex morphology
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice require water gel for survival
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• the preplate fails to split into the marginal zone and the subplate unlike in wild-type mice
• subplate neurons intermingle with cortical plate neurons in a superficial superplate structure unlike in wild-type mice
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• foliation development and layer formation are abnormal
• the boundary between layers is unclear and the granule cells are scattered, particularly in the subcortical region unlike in wild-type mice
• Purkinje cell migration is reduced (41% of cells fail to migrate and 31% migrate partially) compared to in wild-type mice
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• cell bodies are scattered in the hippocampus and interspersed among dendrites that are shorter than normal and exhibit abnormal orientations
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• the dentate gyrus is diffuse, and the separation between the suprapyramidal blade, hilus and infrapyramidal blade is all but gone unlike in wild-type mice
• proliferating subgranule cells are located throughout the dentate gyrus unlike in wild-type mice
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• the pyramidal cell layer in CA1 is split, and neurons are scattered with poor discrimination of the stratum oriens, stratum pyramidale, and stratum radiatum
• proliferating subgranule cells are located throughout the dentate gyrus unlike in wild-type mice
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• laminar structures are absent and cells are distributed randomly
• unlike in wild-type mice, neuronal cell bodies are located below the pial surface
• cortical layering appears to be inverted, as determined by marker expression
• cells infiltrate the marginal zone, the subplate is absent and the superplate structure forms near the pial surface unlike in wild-type mice
• however, ventricular zone cell arrangements are normal
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• dendrites of pyramidal neurons are shorter and heterogeneous in orientation in the cerebral cortex unlike in wild-type mice
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• only 29% of Purkinje cells reach their final destination and extend shorter, less elaborate dendrites into the reduced molecular layer compared to in wild-type mice
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• at 2 to 4 weeks, mice weigh 39% to 59% less than wild-type mice
• after weaning, surviving mice are 15% to 29% smaller than wild-type mice by weight
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• severe
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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