About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zbtb7btm1.1Rbo
targeted mutation 1.1, Remy Bosselut
MGI:3817628
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zbtb7btm1.1Rbo/Zbtb7btm1.1Rbo Not Specified MGI:3817638
cx2
 		Tg(TcrAND)53Hed/?
Zbtb7btm1.1Rbo/Zbtb7btm1.1Rbo 		involves: C57BL/6 * SJL MGI:3817639


Genotype
MGI:3817638
hm1
Allelic
Composition		 Zbtb7btm1.1Rbo/Zbtb7btm1.1Rbo
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7btm1.1Rbo mutation (0 available); any Zbtb7b mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:141145 )
• the thymus contains a large CD4+CD8low population that has a high TCR expression and high CD24 expression
decreased CD4-positive, alpha-beta T cell number ( J:141145 )
• CD4 T cell numbers are severely reduced in the lymph nodes and spleen
abnormal CD8-positive, alpha-beta T cell number ( J:141145 )
• CD8 T cell numbers are increased in the lymph nodes and spleen by 2- to 5- fold

hematopoietic system
abnormal T cell differentiation ( J:141145 )
• the thymus contains a large CD4+CD8low population that has a high TCR expression and high CD24 expression
decreased CD4-positive, alpha-beta T cell number ( J:141145 )
• CD4 T cell numbers are severely reduced in the lymph nodes and spleen
abnormal CD8-positive, alpha-beta T cell number ( J:141145 )
• CD8 T cell numbers are increased in the lymph nodes and spleen by 2- to 5- fold




Genotype
MGI:3817639
cx2
Allelic
Composition		 Tg(TcrAND)53Hed/?
Zbtb7btm1.1Rbo/Zbtb7btm1.1Rbo
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcrAND)53Hed mutation (2 available)
Zbtb7btm1.1Rbo mutation (0 available); any Zbtb7b mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:141145 )
• T cells expressing the transgenic MHC class II-restricted TCR show diversion from the CD4+ lineage to the CD8+ lineage

hematopoietic system
abnormal T cell differentiation ( J:141145 )
• T cells expressing the transgenic MHC class II-restricted TCR show diversion from the CD4+ lineage to the CD8+ lineage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory