Zbtb7b^tm1.1Rbo
Targeted Allele Detail

Summary

• Symbol: Zbtb7b^tm1.1Rbo
• Name: zinc finger and BTB domain containing 7B; targeted mutation 1.1, Remy Bosselut
• MGI ID: MGI:3817628
• Synonyms: ThPok^-, Zbtb7b^-
• Gene: Zbtb7b Location: Chr3:89284953-89300976 bp, - strand Genetic Position: Chr3, 39.09 cM, cytoband A1-A2
• Alliance: Zbtb7b^tm1.1Rbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141145
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was placed into a non-conserved, non-coding portion of exon 3 and a loxP- Frt- flanked neo-cassette was placed 212 bp upstream from the transcription initiation site. Mice were crossed with cre-transgenic mice to delete the coding region and the neo cassette from the germline cells. Gene inactivation was confirmed by a lack of protein detected in immunoblot assays of B cell extracts from homozygotes. (J:141145)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb7b Mutation: 26 strains or lines available

References

• Original: J:141145 Wang L, et al., Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol. 2008 Oct;9(10):1122-30
• All: 14 reference(s)