Phenotypes associated with this allele
cardiovascular system
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• when fed a high fat Western diet for 6-30 weeks, mice develop atherosclerotic aortic lesions of the intimal and medial areas; incidence and severity are similar for Serpine1-deficient or transgenic Apoe-deficient genotypes
• lesions are somewhat larger than those observed on the Ldlr-deficient background
• cellular composition of lesions is similar among all Serpine1-deficient or transgenic, Apoe-deficient genotypes, or Apoe-deficient only mice; at early time points, a greater foam cell content is observed, with more prominent cholesterol clefts and necrotic areas evident with increasing age
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation
(19 available);
any
Ldlr mutation
(76 available)
Tg(CMV-Serpine1)1Dgi mutation
(1 available)
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cardiovascular system
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• when fed a high fat Western diet for 6-30 weeks, mice develop atherosclerotic aortic lesions of the intimal and medial areas; incidence and severity are similar for Serpine1-deficient or transgenic Ldlr-deficient genotypes
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CMV-Serpine1)1Dgi mutation
(1 available)
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cardiovascular system
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N |
• similar to wild-type controls, after 30 weeks of receiving a high fat Western diet, transgenic mice do not display any atherosclerotic lesions
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CMV-Serpine1)1Dgi mutation
(1 available)
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respiratory system
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• bleomycin-induced increase in lung collagen content (determined from hydroxyproline content) is 3.2 fold greater than that in PBS-treated wild-type mice and significantly greater (1.9 fold greater) than that in bleomycin treated wild-type mice at 2 weeks post treatment
• lung fibrin deposition following bleomycin treatment is significantly increased compared to treated wild-type mice
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• mice exhibit increased susceptibility to pulmonary fibrosis following injury or intratracheal induction with bleomycin
(J:140007)
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neoplasm
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N |
• no significant differences are observed compared to controls in terms of primary tumor size of footpad tumors induced by foot pad injection with tumor cells at 10, 17, or 21 days post-injection
• after injection of melanoma cells, number of primary pulmonary metastases post-injection, or tumor burdens initiated by injections of increasing doses of cells do not significantly differ from wild-type controls
• survival times after foot pad tumor removal are not significantly different among Serpine1-deficient, Serpine1-overexpressing transgenic, or wild-type mice
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Analysis Tools