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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Del(5D5Mit73-D5Mit351)5Jcs
deletion, Chr 5, John C Schimenti 5
MGI:3798174
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Del(5D5Mit73-D5Mit351)5Jcs/+ involves: 129S4/SvJae * C3H * C57BL/6J MGI:3798298
ht2
Del(5D5Mit73-D5Mit351)5Jcs/+ involves: 129S4/SvJae * C57BL/6J MGI:3798288


Genotype
MGI:3798298
ht1
Allelic
Composition
Del(5D5Mit73-D5Mit351)5Jcs/+
Genetic
Background
involves: 129S4/SvJae * C3H * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• Background Sensitivity: the severe runting is less severe as the deletion is backcrossed onto the C3H background (J:67077)
• Background Sensitivity: the severe runting is less severe as the deletion is backcrossed onto the C3H background (J:67077)




Genotype
MGI:3798288
ht2
Allelic
Composition
Del(5D5Mit73-D5Mit351)5Jcs/+
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
• some have misshapened palatine ridges (J:67077)
• some have misshapened palatine ridges (J:67077)
• Background Sensitivity: severe growth retardation averaging only 50-80% of the weight of same-sex wildtype littermates (J:67077)
• Background Sensitivity: severe growth retardation averaging only 50-80% of the weight of same-sex wildtype littermates (J:67077)

craniofacial
• Background Sensitivity: the 'Greek warrior helmet' phenotype of domed skull, small ears, and wide set eyes is found on a >50% C57BL/6J background (J:67077)
• Background Sensitivity: the 'Greek warrior helmet' phenotype of domed skull, small ears, and wide set eyes is found on a >50% C57BL/6J background (J:67077)
• in some (J:67077)
• in some (J:67077)
• in the most severe cases the face is asymmetric and/or the jaw bones are asymmetric (J:67077)
• in the most severe cases the face is asymmetric and/or the jaw bones are asymmetric (J:67077)
• some have misshapened palatine ridges (J:67077)
• some have misshapened palatine ridges (J:67077)

hearing/vestibular/ear

limbs/digits/tail

skeleton
• in some (J:67077)
• in some (J:67077)

vision/eye
• found in some (J:67077)
• found in some (J:67077)

digestive/alimentary system
• some have misshapened palatine ridges (J:67077)
• some have misshapened palatine ridges (J:67077)

behavior/neurological
N
• Morris water maze performance normal (J:67077)
• Morris water maze performance normal (J:67077)
• froglike gait with hindlimbs splayed outward during locomotion (J:67077)
• froglike gait with hindlimbs splayed outward during locomotion (J:67077)
• although there is a trend for increased seizure incidence, statistical significance was not found, but severity of seizure is much greater than in controls with half of the seizures in heterozygotes being maximal (J:67077)
• although there is a trend for increased seizure incidence, statistical significance was not found, but severity of seizure is much greater than in controls with half of the seizures in heterozygotes being maximal (J:67077)

nervous system
• although there is a trend for increased seizure incidence, statistical significance was not found, but severity of seizure is much greater than in controls with half of the seizures in heterozygotes being maximal (J:67077)
• although there is a trend for increased seizure incidence, statistical significance was not found, but severity of seizure is much greater than in controls with half of the seizures in heterozygotes being maximal (J:67077)
• intraculminate fissure, posterior fissure, and uvular cus are lacking (J:67077)
• intraculminate fissure, posterior fissure, and uvular cus are lacking (J:67077)
• hypoplasia of the cerebral cortex results in colliculi being more exposed (J:67077)
• hypoplasia of the cerebral cortex results in colliculi being more exposed (J:67077)

Mouse Models of Human Disease
OMIM ID Ref(s)
Wolf-Hirschhorn Syndrome; WHS 194190 J:67077





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory