Phenotypes associated with this allele

• Allele Symbol: Mtbp^tm1Glo
• Allele Name: targeted mutation 1, Guillermina Lozano
• Allele ID: MGI:3794647
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtbp^tm1Glo/Mtbp^tm1Glo	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3803624
ht2	Mtbp^tm1Glo/Mtbp^+	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3803627
cx3	Mtbp^tm1Glo/Mtbp^tm1Glo Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J	MGI:3803625
cx4	Mtbp^tm1Glo/Mtbp^tm1Glo Trp53^tm1Tyj/Trp53^+	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J	MGI:3803626
cx5	Mtbp^tm1Glo/Mtbp^+ Trp53^tm1Tyj/Trp53^+	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J	MGI:3803628

Genotype
MGI:3803624

hm1

• Allelic Composition: Mtbp^tm1Glo/Mtbp^tm1Glo
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:135509 )

• all embryos die between E3.5 and E7.5

Genotype
MGI:3803627

ht2

• Allelic Composition: Mtbp^tm1Glo/Mtbp⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

neoplasm

neoplasm ( J:135509 )

N • 35% of mice develop tumors by 24 months of age which is not statistically different from the 30% incidence that occurs in wild-type littermates

Genotype
MGI:3803625

cx3

• Allelic Composition: Mtbp^tm1Glo/Mtbp^tm1Glo; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:135509 )

• all embryos die between E3.5 and E7.5

Genotype
MGI:3803626

cx4

• Allelic Composition: Mtbp^tm1Glo/Mtbp^tm1Glo; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:135509 )

• all embryos die between E3.5 and E7.5

Genotype
MGI:3803628

cx5

• Allelic Composition: Mtbp^tm1Glo/Mtbp⁺; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

mortality/aging

decreased tumor-free survival time ( J:135509 )

• less than 5% of mice live past two years due to cancerous tumors

neoplasm

increased metastatic potential ( J:135509 )

• mice develop significantly more metastatic tumors than Trp53^tm1Tyj heterozygotes (18.2% vs 2.6%)

• metatastic tumors are found in the lung, liver, kidney, and lymph node

• mouse embryonic fibroblasts cells migrate almost as twice as fast as wild-type MEFs through a matrigel membrane

increased tumor incidence ( J:135509 )

• mice develop tumors with age similar to Trp53^tm1Tyj heterozygotes

• over 95% of mice have tumors by 2 years of age

increased leukemia incidence ( J:135509 )

• is observed in 4.5% of mice by 24 months of age

increased lymphoma incidence ( J:135509 )

• is observed in 20.5% of mice by 24 months of age