All Phenotypes Tg(Pbsn-TAg)15Tvd MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Pten^tm1Ppp/Pten⁺ Tg(Pbsn-TAg)15Tvd/0	involves: 129S1/Sv * C57BL/6 * DBA/2	MGI:4836243
cx2	Tg(Pbsn-TAg)15Tvd/0 Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:4836242
tg3	Tg(Pbsn-TAg)15Tvd/0	involves: C57BL/6 * DBA/2	MGI:4836241

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:103408 )

• onset of lesions is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice; by 8 weeks of age, mutant prostates show pronounced cribriform and tufting of epithelial cells that are not seen until 12 weeks of age in single transgenic Tg(Pbsn-TAg)15Tvd mice

increased prostate gland adenocarcinoma incidence ( J:103408 )

• onset of adenocarcinoma is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis

• some prostate abnormalities are different than in single transgenic Tg(Pbsn-TAg)15Tvd mice; pale cell carcinomas appear at around 17 weeks of age as do large focal adenocarcinomas with abundant cytoplasm and abnormal glandular growth patterns

• tumors show local microinvasion as well as invasion to distant sites in the urogenital system such as the seminal vesicle

increased prostate intraepithelial neoplasia incidence ( J:103408 )

• onset of mPIN is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis

• mPIN lesions increase in severity with age

abnormal prostate gland physiology ( J:103408 )

• epithelial proliferation in the prostate remains similar to single transgenic Tg(Pbsn-TAg)15Tvd mice

• apoptosis in the prostate is reduced compared to single transgenic Tg(Pbsn-TAg)15Tvd mice

reproductive system

increased prostate gland tumor incidence ( J:103408 )

increased prostate gland adenocarcinoma incidence ( J:103408 )

• onset of adenocarcinoma is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis

• tumors show local microinvasion as well as invasion to distant sites in the urogenital system such as the seminal vesicle

increased prostate intraepithelial neoplasia incidence ( J:103408 )

• onset of mPIN is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis

• mPIN lesions increase in severity with age

abnormal prostate gland physiology ( J:103408 )

• epithelial proliferation in the prostate remains similar to single transgenic Tg(Pbsn-TAg)15Tvd mice

• apoptosis in the prostate is reduced compared to single transgenic Tg(Pbsn-TAg)15Tvd mice

neoplasm

increased prostate gland tumor incidence ( J:103408 )

increased prostate gland adenocarcinoma incidence ( J:103408 )

• onset of adenocarcinoma is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis

• tumors show local microinvasion as well as invasion to distant sites in the urogenital system such as the seminal vesicle

increased prostate intraepithelial neoplasia incidence ( J:103408 )

• onset of mPIN is accelerated compared to single transgenic Tg(Pbsn-TAg)15Tvd mice, most likely due to a reduction in apoptosis

• mPIN lesions increase in severity with age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:103408

Allelic Composition	Tg(Pbsn-TAg)15Tvd/0 Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pbsn-TAg)15Tvd mutation (0 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal prostate gland epithelium morphology ( J:103408 )

• proliferation and apoptosis in the prostate remains similar to single transgenic Tg(Pbsn-TAg)15Tvd mice

reproductive system

abnormal prostate gland epithelium morphology ( J:103408 )

• proliferation and apoptosis in the prostate remains similar to single transgenic Tg(Pbsn-TAg)15Tvd mice

Allelic Composition	Tg(Pbsn-TAg)15Tvd/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal prostate gland epithelium morphology ( J:103408 )

• increase in proliferation in prostatic luminal epithelial cells

• 5-6-fold increase in apoptosis in prostatic luminal epithelial cells

prostate gland epithelial hyperplasia ( J:103408 )

• prostates exhibit abnormal gland architecture as early as 6 weeks of age showing focal hyperplasias with nuclear atypia

increased prostate gland adenocarcinoma incidence ( J:103408 )

• develop focally invasive well-differentiated adenocarcinomas by 16 weeks of age

• adenocarcinomas do not become grossly invasive within 22 months of observation, however, they do show microinvasion

increased prostate intraepithelial neoplasia incidence ( J:103408 )

• by 12 weeks of age, mutants exhibit traits of murine prostatic intraepithelial neoplasia (mPIN), including epithelial layer stratification, accompanied by hypercellularity of the fibromuscular stromal cell layer

reproductive system

abnormal prostate gland epithelium morphology ( J:103408 )

• increase in proliferation in prostatic luminal epithelial cells

• 5-6-fold increase in apoptosis in prostatic luminal epithelial cells

prostate gland epithelial hyperplasia ( J:103408 )

• prostates exhibit abnormal gland architecture as early as 6 weeks of age showing focal hyperplasias with nuclear atypia

increased prostate gland adenocarcinoma incidence ( J:103408 )

• develop focally invasive well-differentiated adenocarcinomas by 16 weeks of age

• adenocarcinomas do not become grossly invasive within 22 months of observation, however, they do show microinvasion

increased prostate intraepithelial neoplasia incidence ( J:103408 )

male infertility ( J:103408 )

• aging males exhibit sterility

neoplasm

increased prostate gland adenocarcinoma incidence ( J:103408 )

• develop focally invasive well-differentiated adenocarcinomas by 16 weeks of age

• adenocarcinomas do not become grossly invasive within 22 months of observation, however, they do show microinvasion

increased prostate intraepithelial neoplasia incidence ( J:103408 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:103408

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