Phenotypes associated with this allele

• Allele Symbol: Tg(Myl1-Igf1)1Nros
• Allele Name: transgene insertion 1, Nadia Rosenthal
• Allele ID: MGI:3793794
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Acta1^tm1Hrd/Acta1^+ Tg(Myl1-Igf1)1Nros/?	either: (involves: 129S1/Sv * 129X1/SvJ * FVB/N) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc * FVB/N)	MGI:5425000
cx2	Tg(Myl1-Igf1)1Nros/0 Tg(SOD1*G93A)1Gur/0	involves: C57BL/6 * FVB/N * SJL	MGI:4838155

Genotype
MGI:5425000

cx1

• Allelic Composition: Acta1^tm1Hrd/Acta1⁺; Tg(Myl1-Igf1)1Nros/?
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * FVB/N) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:184588 )

• survival is not affected by the presence of the transgene

behavior/neurological

behavior/neurological phenotype ( J:184588 )

N • mobility in open field tests is normal

increased grip strength ( J:184588 )

• forearm grip strength is improved

muscle

abnormal muscle fiber morphology ( J:184588 )

• nemaline rod pathology is improved

• increased myofiber size

abnormal muscle weight ( J:184588 )

• improved

Genotype
MGI:4838155

cx2

• Allelic Composition: Tg(Myl1-Igf1)1Nros/0; Tg(SOD1*G93A)1Gur/0
• Genetic Background: involves: C57BL/6 * FVB/N * SJL

mortality/aging

premature death ( J:95812 )

• delayed the onset and in particular the progression of disease

• increase the survival by about 30 days to a maximal life span of 175 d

muscle

decreased skeletal muscle fiber diameter ( J:95812 )

• decreased muscle fiber diameter at 123 d and 150 d, compared with Tg(Myl1-Igf1)1Nros mice

• attenuated muscle atrophy, compared with Tg(SOD1*G93A)1Gur mice

centrally nucleated skeletal muscle fibers ( J:95812 )

• at all stages of disease, including at paralysis stage (123 d)

abnormal skeletal muscle fiber type ratio ( J:95812 )

• altered fiber type composition at 138 d with a shift toward a fast fiber type

nervous system

astrocytosis ( J:95812 )

• decrease in astroglial activation at paralysis stage (123 d) in the spinal cord, compared with Tg(SOD1*G93A)1Gur mice

decreased motor neuron number ( J:95812 )

• motor neuron loss is less severe at 112 and 123 d, compared with Tg(SOD1*G93A)1Gur mice