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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc1tm1.1Tyj
targeted mutation 1.1, Tyler Jacks
MGI:3793628
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mirc1tm1.1Tyj/Mirc1tm1.1Tyj involves: 129S4/SvJae * C57BL/6 * SJL MGI:3809717
cn2
 		Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd1tm1.1Pcha/Pkd1tm2Som
Tg(Cdh16-cre)91Igr/0 		involves: 129 * 129S4/SvJae * C57BL/6 * ICR MGI:6317335
cn3
 		Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
Tg(Cdh16-cre)91Igr/0 		involves: 129 * 129S4/SvJae * C57BL/6 * ICR MGI:6317339
cn4
 		Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd2tm3Som/Pkd2tm3Som
Tg(Pkhd1-cre)1Igr/0 		involves: 129S4/SvJae * C57BL/6 MGI:6317330
cn5
 		Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd1tm2Som/Pkd1tm2Som
Tg(Cdh16-cre)91Igr/0 		involves: 129S4/SvJae * C57BL/6 * ICR MGI:6317328


Genotype
MGI:3809717
hm1
Allelic
Composition		 Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.1Tyj mutation (1 available); any Mirc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:134861 )
• viable with no obvious abnormalities




Genotype
MGI:6317335
cn2
Allelic
Composition		 Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd1tm1.1Pcha/Pkd1tm2Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.1Tyj mutation (1 available); any Mirc1 mutation (6 available)
Pkd1tm1.1Pcha mutation (0 available); any Pkd1 mutation (153 available)
Pkd1tm2Som mutation (0 available); any Pkd1 mutation (153 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:244067 )
N
• renal function and renal interstitial fibrosis are improved compared to conditional Pkd1 compound heterozygotes and mice live past 1 year of age
decreased kidney cell proliferation ( J:244067 )
• mice show a decrease in cyst epithelial cell proliferation compared to conditional Pkd1 compound heterozygotes
kidney cyst ( J:244067 )
• cyst size is reduced compared to conditional Pkd1 compound heterozygotes
decreased kidney weight ( J:244067 )
• kidney weight is reduced compared to conditional Pkd1 compound heterozygotes

cellular
abnormal peroxisome morphology ( J:244067 )
• the number of peroxisomes in the kidneys is reduced compared to conditional Pkd1 compound heterozygotes
decreased kidney cell proliferation ( J:244067 )
• mice show a decrease in cyst epithelial cell proliferation compared to conditional Pkd1 compound heterozygotes
increased fatty acid oxidation ( J:244067 )
• fatty acid oxidation is increased in kidneys compared to conditional Pkd1 compound heterozygotes
abnormal redox activity ( J:244067 )
• reactive oxidative species level is decreased in the kidneys compared to conditional Pkd1 compound heterozygotes

homeostasis/metabolism
increased fatty acid oxidation ( J:244067 )
• fatty acid oxidation is increased in kidneys compared to conditional Pkd1 compound heterozygotes
decreased circulating creatinine level ( J:244067 )
• mice show decreased levels at 3, 7, and 15 weeks of age compared to conditional Pkd1 compound heterozygotes

growth/size/body
kidney cyst ( J:244067 )
• cyst size is reduced compared to conditional Pkd1 compound heterozygotes




Genotype
MGI:6317339
cn3
Allelic
Composition		 Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.1Tyj mutation (1 available); any Mirc1 mutation (6 available)
Pkd1tm1.1Pcha mutation (0 available); any Pkd1 mutation (153 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:244067 )
N
• mice exhibit attenuated cyst growth and reduced renal fibrosis compared to single Pkd1tm1.1Pcha homozygotes

homeostasis/metabolism
decreased blood urea nitrogen level ( J:244067 )
• mice exhibit lower blood urea nitrogen (BUN) levels compared to single Pkd1tm1.1Pcha homozygotes




Genotype
MGI:6317330
cn4
Allelic
Composition		 Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd2tm3Som/Pkd2tm3Som
Tg(Pkhd1-cre)1Igr/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.1Tyj mutation (1 available); any Mirc1 mutation (6 available)
Pkd2tm3Som mutation (0 available); any Pkd2 mutation (84 available)
Tg(Pkhd1-cre)1Igr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:244067 )
• mice have a median survival of 127 days which is 149% increase in median survival compared to single conditional Pkd2 mutants

renal/urinary system
decreased kidney cell proliferation ( J:244067 )
• mice show a 58.9% decrease in the number of proliferating cyst epithelial cells compared to single conditional Pkd2 mutants
kidney cyst ( J:244067 )
• mice show a 15.8% reduction in cyst index compared to single conditional Pkd2 mutants

cellular
decreased kidney cell proliferation ( J:244067 )
• mice show a 58.9% decrease in the number of proliferating cyst epithelial cells compared to single conditional Pkd2 mutants

homeostasis/metabolism
decreased circulating creatinine level ( J:244067 )
• mice show a 31.8% improvement in serum creatinine levels compared to single conditional Pkd2 mutants

growth/size/body
kidney cyst ( J:244067 )
• mice show a 15.8% reduction in cyst index compared to single conditional Pkd2 mutants




Genotype
MGI:6317328
cn5
Allelic
Composition		 Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd1tm2Som/Pkd1tm2Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.1Tyj mutation (1 available); any Mirc1 mutation (6 available)
Pkd1tm2Som mutation (0 available); any Pkd1 mutation (153 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:244067 )
• mice exhibit a median survival of 21 days which is a 50% improvement compared to single Pkd1 conditional mutants

renal/urinary system
decreased kidney cell proliferation ( J:244067 )
• the number of proliferating cyst epithelial cells is reduced by 78.7% compared to single Pkd1 conditional mutants
decreased kidney weight ( J:244067 )
• mice exhibit a 26.8% reduction in kidney-weight-to-body-weight ratio compared to single Pkd1 conditional mutants

cellular
decreased kidney cell proliferation ( J:244067 )
• the number of proliferating cyst epithelial cells is reduced by 78.7% compared to single Pkd1 conditional mutants

homeostasis/metabolism
decreased circulating creatinine level ( J:244067 )
• mice exhibit a 22% reduction in serum creatinine levels compared to single Pkd1 conditional mutants




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory