Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Wrst mutation
(1 available);
any
En1 mutation
(32 available)
Upf2tm1Btp mutation
(0 available);
any
Upf2 mutation
(62 available)
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nervous system
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• increased apoptotic cells in the cerebellum in both the ventricular zone and the prospective white matter
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• in the ventricular zone progenitors at E13.5
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• missing at E13.5 and P0
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• grossly hypoplastic being nearly absent
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• grossly hypoplastic being nearly absent
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• grossly being nearly absent
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• at E13.5 in the cerebellum
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cellular
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• increased apoptotic cells in the cerebellum in both the ventricular zone and the prospective white matter
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• in the ventricular zone progenitors at E13.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation
(14 available);
any
Lyz2 mutation
(41 available)
Upf2tm1Btp mutation
(0 available);
any
Upf2 mutation
(62 available)
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immune system
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N |
• no abnormalities are observed in cells of the myeloid lineage
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mx1-cre)1Cgn mutation
(7 available)
Upf2tm1Btp mutation
(0 available);
any
Upf2 mutation
(62 available)
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mortality/aging
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• induction of Cre by pI-pC administration leads to death within 10 days with a median survival time of 6 days after first injection of pI-pC
• lethally irradiated wild-type mice that receive mutant bone marrow die within 11 days of Cre induction in the bone marrow derived cells
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hematopoietic system
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• there is a profound reduction in the ability of CD4 and CD8 T cells to proliferate in response to mitogenic stimuli 6 days after induction of Cre by pI-pC administration
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• anemia results within 6 days after induction of Cre by pI-pC administration
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• there is almost a complete absence of nucleated cells in the bone marrow including stem and progenitor cells 6 days after induction of Cre by pI-pC administration
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• there is almost a complete absence of granulocytes in the bone marrow 6 days after induction of Cre by pI-pC administration
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• mean RBC counts are reduced by more than half 6 days after induction of Cre by pI-pC administration
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• percentage of hematocrit is reduced by more than half 6 days after induction of Cre by pI-pC administration
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• hemoglobulin content is reduced by more than half 6 days after induction of Cre by pI-pC administration
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• there is almost a complete absence of granulocytes in the bone marrow 6 days after induction of Cre by pI-pC administration
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• there is almost a complete absence of B-cells in the bone marrow 6 days after induction of Cre by pI-pC administration
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• there is almost a complete absence of hematopoietic progenitors in the bone marrow 6 days after induction of Cre by pI-pC administration
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immune system
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• there is a profound reduction in the ability of CD4 and CD8 T cells to proliferate in response to mitogenic stimuli 6 days after induction of Cre by pI-pC administration
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• there is almost a complete absence of granulocytes in the bone marrow 6 days after induction of Cre by pI-pC administration
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• there is almost a complete absence of B-cells in the bone marrow 6 days after induction of Cre by pI-pC administration
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cellular
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• there is a profound reduction in the ability of CD4 and CD8 T cells to proliferate in response to mitogenic stimuli 6 days after induction of Cre by pI-pC administration
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)548Jxm mutation
(2 available)
Upf2tm1Btp mutation
(0 available);
any
Upf2 mutation
(62 available)
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immune system
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• significant reduction in size of the thymus with cellularity decreased almost 3-fold
• the percentage of apoptotic cells in the thymus is doubled
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• unproductive transcripts with premature stop codons is detectable in 29% of single positive T cells
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• there is a 3-fold reduction in the number of double positive T cells found in the thymus
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• there is a 4- to 5-fold reduction in CD4 T cells found in the thymus
• the number of CD4 T cells found in the periphery is 30% that of wild-type
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• there is a 2-fold to 3-fold reduction in T cell numbers
• the number of CD8 T cells found in the periphery is 30% that of wild-type
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hematopoietic system
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• significant reduction in size of the thymus with cellularity decreased almost 3-fold
• the percentage of apoptotic cells in the thymus is doubled
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• unproductive transcripts with premature stop codons is detectable in 29% of single positive T cells
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• there is a 3-fold reduction in the number of double positive T cells found in the thymus
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• there is a 4- to 5-fold reduction in CD4 T cells found in the thymus
• the number of CD4 T cells found in the periphery is 30% that of wild-type
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• there is a 2-fold to 3-fold reduction in T cell numbers
• the number of CD8 T cells found in the periphery is 30% that of wild-type
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endocrine/exocrine glands
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• significant reduction in size of the thymus with cellularity decreased almost 3-fold
• the percentage of apoptotic cells in the thymus is doubled
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Atoh1-cre)1Bfri mutation
(1 available)
Upf2tm1Btp mutation
(0 available);
any
Upf2 mutation
(62 available)
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nervous system
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• reduced fraction of granule cell precursors exiting the cell cycle in the anterior lobes of the cerebellum
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• no clear separation of the inner and outer external granule cell layer
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• at P6 in the inner granule layer
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• reduced length with failure of Purkinje cells to form a monolayer
• however, the posterior lobes are normal
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cellular
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• reduced fraction of granule cell precursors exiting the cell cycle in the anterior lobes of the cerebellum
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Analysis Tools