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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adipor2tm2Dgen
targeted mutation 2, Deltagen
MGI:3770154
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adipor2tm2Dgen/Adipor2tm2Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3770157


Genotype
MGI:3770157
hm1
Allelic
Composition
Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipor2tm2Dgen mutation (0 available); any Adipor2 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice gain less weight in response to a high fat diet than do wild-type mice
• while cholesterol levels of mice on a high fat diet increase they remain lower than in similarly treated wild-type mice
• while HDL cholesterol levels of mice on a high fat diet increase they remain lower than in similarly treated wild-type mice
• while LDL/lgHDL cholesterol levels of mice on a high fat diet increase they remain lower than in similarly treated wild-type mice
• while VLDL cholesterol levels of mice on a high fat diet increase they remain lower than in similarly treated wild-type mice
• while triglyceride levels of mice on a high fat diet increase they remain lower than in similarly treated wild-type mice
• when fed a high fat diet mice exhibit less diet-induced insulin resistance compared to wild-type mice
• 186 mg/dl compared to 143 mg/dl in wild-type mice on a high fat diet
• while insulin levels increase in response to a high fat diet the increase is less than in wild-type mice
• when fed a high fat diet, adiponectin plasma levels rise early during the diet and continue to climb as they decrease in wild-type mice

endocrine/exocrine glands
• unlike in wild-type mice fed a high fat diet, the number and size of pancreatic beta cells is not increased

growth/size/body
• mice gain less weight in response to a high fat diet than do wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory