• mice are healthy and fertile

• tamoxifen-treated mice exhibit fewer dystrophic neurite clusters and few isolated neurites with residual bodies compared with control mice expressing Tg(APPswe,PSEN1dE9)85Dbo

• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo

• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo

• mice are slightly less able to hold onto a hanging wire than wild-type mice

• however, righting behavior is normal

• after beta-amyloid 42 stimulation, tamoxifen-treated neurons remain viable and do not exhibit increased caspase 3 activity unlike control neurons

• after beta-amyloid 42 stimulation, tamoxifen-treated neurons remain viable and do not exhibit increased caspase 3 activity unlike control neurons

• tamoxifen-treated neurons exhibit normal increases in neuron apoptosis following beta-amyloid 42 stimulation (J:178060)

• mice die by 21 days

• radial migration of late-born neurons is delayed

• however, lamination of the cerebral cortex and radial glial cell formations are normal

• at P20, the thickness of the corpus callosum is decreased due to defasciulation of cortical afferents

• at P20, the thickness of the anterior commissure is decreased due to defasciulation of cortical afferents

• unlike in wild-type mice, Purkinje cells that normally align beneath the inner granule layer are malpositioned

• at P20, the Purkinje cell layer is disorganized

• however, arborization of dendrites is normal

• Purkinje cell size is reduced by 25% compared to wild-type

• unlike in wild-type mice, the inner granule layer is loosely packed and Purkinje cells that normally align beneath it are malpositioned

• at P14, mice exhibit impaired righting reflex when placed on their backs indicating decreased motor balance and coordination

• between P13 and P15, mice exhibit whole-body tremors

• between P13 and P15

• in a hanging wire test, mice are 5 times less able to hold onto a hanging wire

• between P13 and P15, mice exhibit an awkward gait

• mice are noticeably smaller 7 days after birth and weight 40% of wild-type by day 20

• although mice are born normal they stop growing a few days after birth

• radial migration of late-born neurons is delayed

• however, lamination of the cerebral cortex and radial glial cell formations are normal