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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Map2k4tm1Ctr
targeted mutation 1, Cathy Tournier
MGI:3769117
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Map2k4tm1Ctr/Map2k4tm1Ctr involves: C57BL/6 MGI:3769121
cn2
Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(APPswe,PSEN1dE9)85Dbo/0
Tg(Camk2a-cre/ERT2)2Gsc/0
involves: C3H * C57BL/6 * FVB/N MGI:5297909
cn3
Map2k4tm1Ctr/Map2k4tm1Ctr
Tg(ACTA1-cre)1Mll/?
involves: C57BL/6 MGI:3769134
cn4
Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(CAG-cre/Esr1*)5Amc/0
involves: C57BL/6 * CBA MGI:5297908
cn5
Map2k4tm1Ctr/Map2k4tm1Ctr
Tg(CAG-cre/Esr1*)5Amc/0
involves: C57BL/6 * CBA MGI:5297910
cn6
Map2k4tm1Ctr/Map2k4tm1Ctr
Tg(Nes-cre)1Kln/?
involves: C57BL/6 * SJL MGI:3769122


Genotype
MGI:3769121
hm1
Allelic
Composition
Map2k4tm1Ctr/Map2k4tm1Ctr
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Ctr mutation (0 available); any Map2k4 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are healthy and fertile




Genotype
MGI:5297909
cn2
Allelic
Composition
Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(APPswe,PSEN1dE9)85Dbo/0
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background
involves: C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Ctr mutation (0 available); any Map2k4 mutation (16 available)
Map2k7tm1Rjd mutation (0 available); any Map2k7 mutation (6 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation (0 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo
• tamoxifen-treated mice exhibit fewer dystrophic neurite clusters and few isolated neurites with residual bodies compared with control mice expressing Tg(APPswe,PSEN1dE9)85Dbo

homeostasis/metabolism
• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo




Genotype
MGI:3769134
cn3
Allelic
Composition
Map2k4tm1Ctr/Map2k4tm1Ctr
Tg(ACTA1-cre)1Mll/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Ctr mutation (0 available); any Map2k4 mutation (16 available)
Tg(ACTA1-cre)1Mll mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice are slightly less able to hold onto a hanging wire than wild-type mice
• however, righting behavior is normal




Genotype
MGI:5297908
cn4
Allelic
Composition
Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Ctr mutation (0 available); any Map2k4 mutation (16 available)
Map2k7tm1Rjd mutation (0 available); any Map2k7 mutation (6 available)
Tg(CAG-cre/Esr1*)5Amc mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• after beta-amyloid 42 stimulation, tamoxifen-treated neurons remain viable and do not exhibit increased caspase 3 activity unlike control neurons

nervous system
• after beta-amyloid 42 stimulation, tamoxifen-treated neurons remain viable and do not exhibit increased caspase 3 activity unlike control neurons




Genotype
MGI:5297910
cn5
Allelic
Composition
Map2k4tm1Ctr/Map2k4tm1Ctr
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Ctr mutation (0 available); any Map2k4 mutation (16 available)
Tg(CAG-cre/Esr1*)5Amc mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• tamoxifen-treated neurons exhibit normal increases in neuron apoptosis following beta-amyloid 42 stimulation




Genotype
MGI:3769122
cn6
Allelic
Composition
Map2k4tm1Ctr/Map2k4tm1Ctr
Tg(Nes-cre)1Kln/?
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Ctr mutation (0 available); any Map2k4 mutation (16 available)
Tg(Nes-cre)1Kln mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
• radial migration of late-born neurons is delayed
• however, lamination of the cerebral cortex and radial glial cell formations are normal
• at P20, the thickness of the corpus callosum is decreased due to defasciulation of cortical afferents
• at P20, the thickness of the anterior commissure is decreased due to defasciulation of cortical afferents
• unlike in wild-type mice, Purkinje cells that normally align beneath the inner granule layer are malpositioned
• at P20, the Purkinje cell layer is disorganized
• however, arborization of dendrites is normal
• Purkinje cell size is reduced by 25% compared to wild-type
• unlike in wild-type mice, the inner granule layer is loosely packed and Purkinje cells that normally align beneath it are malpositioned

behavior/neurological
• at P14, mice exhibit impaired righting reflex when placed on their backs indicating decreased motor balance and coordination
• between P13 and P15, mice exhibit whole-body tremors
• between P13 and P15
• in a hanging wire test, mice are 5 times less able to hold onto a hanging wire
• between P13 and P15, mice exhibit an awkward gait

growth/size/body
• mice are noticeably smaller 7 days after birth and weight 40% of wild-type by day 20
• although mice are born normal they stop growing a few days after birth

cellular
• radial migration of late-born neurons is delayed
• however, lamination of the cerebral cortex and radial glial cell formations are normal





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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory