Mouse Genome Informatics
hm1
    Map2k4tm1Ctr/Map2k4tm1Ctr
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• mice are healthy and fertile


Mouse Genome Informatics
cn2
    Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(APPswe,PSEN1dE9)85Dbo/0
Tg(Camk2a-cre/ERT2)2Gsc/0

involves: C3H * C57BL/6 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo
• tamoxifen-treated mice exhibit fewer dystrophic neurite clusters and few isolated neurites with residual bodies compared with control mice expressing Tg(APPswe,PSEN1dE9)85Dbo

homeostasis/metabolism
• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo


Mouse Genome Informatics
cn3
    Map2k4tm1Ctr/Map2k4tm1Ctr
Tg(ACTA1-cre)1Mll/?

involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• mice are slightly less able to hold onto a hanging wire than wild-type mice
• however, righting behavior is normal


Mouse Genome Informatics
cn4
    Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(CAG-cre/Esr1*)5Amc/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cellular
• after beta-amyloid 42 stimulation, tamoxifen-treated neurons remain viable and do not exhibit increased caspase 3 activity unlike control neurons

nervous system
• after beta-amyloid 42 stimulation, tamoxifen-treated neurons remain viable and do not exhibit increased caspase 3 activity unlike control neurons


Mouse Genome Informatics
cn5
    Map2k4tm1Ctr/Map2k4tm1Ctr
Tg(CAG-cre/Esr1*)5Amc/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• tamoxifen-treated neurons exhibit normal increases in neuron apoptosis following beta-amyloid 42 stimulation (J:178060)


Mouse Genome Informatics
cn6
    Map2k4tm1Ctr/Map2k4tm1Ctr
Tg(Nes-cre)1Kln/?

involves: C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice die by 21 days

nervous system
• radial migration of late-born neurons is delayed
• however, lamination of the cerebral cortex and radial glial cell formations are normal
• at P20, the thickness of the corpus callosum is decreased due to defasciulation of cortical afferents
• at P20, the thickness of the anterior commissure is decreased due to defasciulation of cortical afferents
• unlike in wild-type mice, Purkinje cells that normally align beneath the inner granule layer are malpositioned
• at P20, the Purkinje cell layer is disorganized
• however, arborization of dendrites is normal
• Purkinje cell size is reduced by 25% compared to wild-type
• unlike in wild-type mice, the inner granule layer is loosely packed and Purkinje cells that normally align beneath it are malpositioned

behavior/neurological
• at P14, mice exhibit impaired righting reflex when placed on their backs indicating decreased motor balance and coordination
• between P13 and P15, mice exhibit whole-body tremors
• between P13 and P15
• in a hanging wire test, mice are 5 times less able to hold onto a hanging wire
• between P13 and P15, mice exhibit an awkward gait

growth/size
• mice are noticeably smaller 7 days after birth and weight 40% of wild-type by day 20
• although mice are born normal they stop growing a few days after birth

cellular
• radial migration of late-born neurons is delayed
• however, lamination of the cerebral cortex and radial glial cell formations are normal