About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dsg4hage
hage
MGI:3766998
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Dsg4hage/Dsg4hage
Faslpr/Faslpr
X/Yaa
EOD-Dsg4hage MGI:3812133


Genotype
MGI:3812133
cx1
Allelic
Composition
Dsg4hage/Dsg4hage
Faslpr/Faslpr
X/Yaa
Genetic
Background
EOD-Dsg4hage
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg4hage mutation (0 available); any Dsg4 mutation (50 available)
Faslpr mutation (24 available); any Fas mutation (54 available)
Yaa mutation (10 available); any Yaa mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the mean life span of these male mice is 99 days, which is significantly longer than the 88 day mean lifespan that males from this strain normally live

growth/size/body
• mice are generally smaller than controls

immune system
• increased mast cell numbers are found in the superficial layer of the epidermis, with about a 3-fold increase over controls
• the characteristic B220+Thy1+ T cells population found in the spleen of mice carrying the Faslps allele is reduced by more than 5-fold in these mice

hematopoietic system
• increased mast cell numbers are found in the superficial layer of the epidermis, with about a 3-fold increase over controls
• the characteristic B220+Thy1+ T cells population found in the spleen of mice carrying the Faslps allele is reduced by more than 5-fold in these mice

integument
• pups have scanty growth of short hair on the head and back
• the number of hair follicles in a given patch of skin appears to be higher than controls but counting is difficult because of the unusual orientation of the follicles
• axes of hair shafts are randomly oriented, with some being horizontal to the skin layer
• mice fail to grow vibrissae hairs
• mice have thick skin with hyperplasia of the epidermis that is prone to injury

Mouse Models of Human Disease
OMIM ID Ref(s)
Hypotrichosis 6; HYPT6 607903 J:140028





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/15/2016
MGI 6.04
The Jackson Laboratory