Mouse Genome Informatics
cx1
    Dsg4hage/Dsg4hage
Faslpr/Faslpr
X/Yaa

EOD-Dsg4hage
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the mean life span of these male mice is 99 days, which is significantly longer than the 88 day mean lifespan that males from this strain normally live

growth/size/body
• mice are generally smaller than controls

immune system
• increased mast cell numbers are found in the superficial layer of the epidermis, with about a 3-fold increase over controls
• the characteristic B220+Thy1+ T cells population found in the spleen of mice carrying the Faslps allele is reduced by more than 5-fold in these mice

hematopoietic system
• increased mast cell numbers are found in the superficial layer of the epidermis, with about a 3-fold increase over controls
• the characteristic B220+Thy1+ T cells population found in the spleen of mice carrying the Faslps allele is reduced by more than 5-fold in these mice

integument
• pups have scanty growth of short hair on the head and back
• the number of hair follicles in a given patch of skin appears to be higher than controls but counting is difficult because of the unusual orientation of the follicles
• axes of hair shafts are randomly oriented, with some being horizontal to the skin layer
• mice fail to grow vibrissae hairs
• mice have thick skin with hyperplasia of the epidermis that is prone to injury

Mouse Models of Human Disease
OMIM IDRef(s)
Hypotrichosis 6; HYPT6 607903 J:140028