Analysis Tools
integument
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• mice exhibit an abnormal skin phenotype similar to that observed in Tg(KRT14-Il1f5)1Hblu mice
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Allele Symbol Allele Name Allele ID |
Tg(KRT14-Il1f6)1Hblu transgene insertion 1, Hal Blumberg MGI:3762035 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an abnormal skin phenotype similar to that observed in Tg(KRT14-Il1f5)1Hblu mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only 1 mouse was found at weaning and 13 dead mice were recovered prior to weaning with milk in their stomachs but small and dehydrated
• however, treatment with 50 ug M616 at P1, 3 and 5 rescues lethality
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• mice exhibit a dilation of superficial dermal blood vessels
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• mice that die during the postnatal period have a dehydrated appearance
• however, skin barrier function at E18.5 and P3 is normal
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• mice are smaller than wild-type mice
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• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
• while treatment with 50 ug M616 at P1, 3 and 5 rescues lethality mice develop severe lesions on their face, neck and ears by 4 to 6 weeks when the treatment is withdrawn
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• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
• while treatment with 50 ug M616 at P1, 3 and 5 rescues lethality mice develop severe lesions on their face, neck and ears by 4 to 6 weeks when the treatment is withdrawn
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• mice exhibit intracorneal and intraepithelial pustules, nucleated corneocytes, parakerototic and orthokeratotic hyperkeratinosis, dilated superficial dermal blood vessels, and a mixed dermal inflammatory infiltrate
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• mice exhibit orthokeratotic hyperkeratinosis
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• mice exhibit parakerototic hyperkeratinosis
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• at P3 mice develop an abnormal skin phenotype resembling blistering
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a dilation of superficial dermal blood vessels
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• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
|
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• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
|
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• mice exhibit intracorneal and intraepithelial pustules, parakerototic and orthokeratotic hyperkeratinosis, dilated superficial dermal blood vessels, and a mixed dermal inflammatory infiltrate
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• mice exhibit orthokeratotic hyperkeratinosis
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• mice exhibit parakeratotic hyperkeratinosis
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• mice have regions of thick and scaly skin
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• mice have regions of thick and scaly skin
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an abnormal skin phenotype similar to that observed in Tg(KRT14-Il1f5)1Hblu mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an abnormal skin phenotype similar to that observed in Tg(KRT14-Il1f5)1Hblu mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an abnormal skin phenotype similar to that observed in Tg(KRT14-Il1f5)1Hblu mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop ringtail
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• mice are small
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• mice produce elevated levels of GM-CSF (granulocyte monocyte colony stimulating factor), MIP-2 (macrophage-inflammatory protein-2), GCP-2 (granulocyte chemotactic protein) and MCP-3 (monocyte chemotactic protein-3)
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• mice develop skin inflammation with infiltrate composed of neutrophils, macrophages and lymphocytes
• mice exhibit increased immunoreactivity for markers of keratinocyte hyperproliferation, macrophages, epidermal Langerhans and dermal dendritic cells, inflammation, and T lymphocytes
• peak inflammatory response occurs at P7 and resolves by P21
• however, immune infiltrate can be reduced by treatment with anti-TNF-alpha or anti-Gr1 antibodies
• while treatment with anti-Gr1 antibodies reduced the number of infiltrating neutrophils it does not eliminate them
mice exhibit an increase in CD3+ T lymphocytes in the skin compared to wild-type mice
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• mice produce elevated levels of GM-CSF (granulocyte monocyte colony stimulating factor), MIP-2 (macrophage-inflammatory protein-2), GCP-2 (granulocyte chemotactic protein) and MCP-3 (monocyte chemotactic protein-3)
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• mice develop skin inflammation with infiltrate composed of neutrophils, macrophages and lymphocytes
• mice exhibit increased immunoreactivity for markers of keratinocyte hyperproliferation, macrophages, epidermal Langerhans and dermal dendritic cells, inflammation, and T lymphocytes
• peak inflammatory response occurs at P7 and resolves by P21
• however, immune infiltrate can be reduced by treatment with anti-TNF-alpha or anti-Gr1 antibodies
• while treatment with anti-Gr1 antibodies reduced the number of infiltrating neutrophils it does not eliminate them
mice exhibit an increase in CD3+ T lymphocytes in the skin compared to wild-type mice
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• while wild-type mice epidermis decreases in thickness between P1 and P21, mice exhibit increased epidermal thickness with the maximal difference at P5
• however, epidermal thickness can be reduced by treatment with anti-TNF-alpha antibodies
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• recurrence of skin lesions on the face, snout and ears develops at 6 month of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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