Il1rl2^tm1Hblu
Targeted Allele Detail

Summary

• Symbol: Il1rl2^tm1Hblu
• Name: interleukin 1 receptor-like 2; targeted mutation 1, Hal Blumberg
• MGI ID: MGI:3762029
• Synonyms: IL1RL2^-, IL-1Rrp2^-, IL-36R^-
• Gene: Il1rl2 Location: Chr1:40363770-40406722 bp, + strand Genetic Position: Chr1, 18.96 cM
• Alliance: Il1rl2^tm1Hblu page

Il1rl2^tm1Hblu/Il1rl2^tm1Hblu and Il36rn^tm1Kopf/Il36rn^tm1Kopf mice show different susceptibilities to IMQ-induced psoriasiform dermatitis

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126327
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were replaced with a lacZ-neo cassette. Insertion was confirmed by Southern blot analysis. (J:126327)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1rl2 Mutation: 45 strains or lines available

References

• Original: J:126327 Blumberg H, et al., Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. J Exp Med. 2007 Oct 29;204(11):2603-14
• All: 18 reference(s)