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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
SufuGt(XB699)Byg
gene trap XB699, BayGenomics
MGI:3759455
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
SufuGt(XB699)Byg/SufuGt(XB699)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:3759456
cx2
SufuGt(XB699)Byg/Sufu+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:3759457


Genotype
MGI:3759456
hm1
Allelic
Composition
SufuGt(XB699)Byg/SufuGt(XB699)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SufuGt(XB699)Byg mutation (0 available); any Sufu mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice are recovered after E10 due to defects in neural tube closure and heart abnormalities

nervous system

cardiovascular system

embryo




Genotype
MGI:3759457
cx2
Allelic
Composition
SufuGt(XB699)Byg/Sufu+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SufuGt(XB699)Byg mutation (0 available); any Sufu mutation (33 available)
Trp53tm1Tyj mutation (9 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• unlike SufuGT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis

muscle
• unlike SufuGT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma

mortality/aging
• mice die around 4 months of age compared to Trp53tm1Tyj homozygotes that survive to 5 months

neoplasm
• unlike SufuGT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma
• unlike SufuGT(XB699)Byg heterozygotes, 8 of 55 mice develop lymphomas or thymomas likely due to Trp53tm1Tyj
• unlike SufuGT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis

Mouse Models of Human Disease
OMIM ID Ref(s)
Medulloblastoma; MDB 155255 J:173443





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory