Mouse Genome Informatics
hm1
    SufuGt(XB699)Byg/SufuGt(XB699)Byg
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• no mice are recovered after E10 due to defects in neural tube closure and heart abnormalities

nervous system

cardiovascular system

embryogenesis


Mouse Genome Informatics
cx2
    SufuGt(XB699)Byg/Sufu+
Trp53tm1Tyj/Trp53tm1Tyj

involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice die around 4 months of age compared to Trp53tm1Tyj homozygotes that survive to 5 months

tumorigenesis
• unlike SufuGT(XB699)Byg heterozygotes, 8 of 55 mice develop lymphomas or thymomas likely due to Trp53tm1Tyj
• unlike SufuGT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis
• unlike SufuGT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma

Mouse Models of Human Disease
OMIM IDRef(s)
Medulloblastoma; MDB 155255 J:173443