Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SufuGt(XB699)Byg mutation
(0 available);
any
Sufu mutation
(59 available)
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mortality/aging
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• no mice are recovered after E10 due to defects in neural tube closure and heart abnormalities
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nervous system
cardiovascular system
embryo
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SufuGt(XB699)Byg mutation
(0 available);
any
Sufu mutation
(59 available)
Trp53tm1Tyj mutation
(12 available);
any
Trp53 mutation
(232 available)
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mortality/aging
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• mice die around 4 months of age compared to Trp53tm1Tyj homozygotes that survive to 5 months
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neoplasm
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• unlike SufuGT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma
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• unlike SufuGT(XB699)Byg heterozygotes, 8 of 55 mice develop lymphomas or thymomas likely due to Trp53tm1Tyj
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• unlike SufuGT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis
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nervous system
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• unlike SufuGT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis
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muscle
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• unlike SufuGT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma
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