Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation
(4 available)
Thratm1Ffla mutation
(0 available);
any
Thra mutation
(39 available)
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mortality/aging
nervous system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
Thratm1Ffla mutation
(0 available);
any
Thra mutation
(39 available)
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nervous system
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• authors state that mice treated at E17.5 with tamoxifen exhibit a phenotype similar but less severe to that observed in Thratm1Ffla Tg(Sycp1-cre)4Min mice
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growth/size/body
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• authors state that mice treated at E17.5 with tamoxifen exhibit a phenotype similar but less severe to that observed in Thratm1Ffla Tg(Sycp1-cre)4Min mice
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cardiovascular system
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• authors state that mice treated at E17.5 with tamoxifen exhibit a phenotype similar but less severe to that observed in Thratm1Ffla Tg(Sycp1-cre)4Min mice
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skeleton
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• authors state that mice treated at E17.5 with tamoxifen exhibit a phenotype similar but less severe to that observed in Thratm1Ffla Tg(Sycp1-cre)4Min mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Sycp1-cre)4Min mutation
(1 available)
Thratm1Ffla mutation
(0 available);
any
Thra mutation
(39 available)
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mortality/aging
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• 48% of mice do not reach adulthood
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reproductive system
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• despite no obvious defects in ovary morphology, females are sterile
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nervous system
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• unlike in wild-type mice, at P21 the external granule layer persists and granular precursor cells are still present
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• at P15, arborization of Purkinje cell dendrites is reduced by number and size of dendritic spines
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behavior/neurological
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• mice display an ataxic bearing and spread their hindlimbs to maintain their posture
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growth/size/body
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• while surviving mice gain weight they suffer from a permanent and disproportioned dwarfism
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homeostasis/metabolism
cardiovascular system
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• 224+/-24 beats per minute compared to 393+/-45 beats per minute in wild-type mice
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• mice sometime display cardiac arrhythmia
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skeleton
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• ossification of the long bones is delayed
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hematopoietic system
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• at P15, spleen weight is decreased (26.9+/-12.2 mg compared to 39.5+/-9.1 mg in wild-type mice)
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vision/eye
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• eyelid opening was delayed to P25 compared to P15 in wild-type mice
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immune system
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• at P15, spleen weight is decreased (26.9+/-12.2 mg compared to 39.5+/-9.1 mg in wild-type mice)
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Analysis Tools
