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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(dlx5a-cre)1Mekk
transgene insertion 1, Marc Ekker
MGI:3758328
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ntrk1tm2.1Lfr/Ntrk1tm2.1Lfr
Tg(dlx5a-cre)1Mekk/0
involves: 129 * C57BL/6 * CD-1 * SJL MGI:5319088
cn2
Cdkl5tm1.1Cogr/?
Tg(dlx5a-cre)1Mekk/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * CD-1 MGI:5574069
cn3
Cdkl5tm1.1Cogr/Y
Tg(dlx5a-cre)1Mekk/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * CD-1 MGI:5574068
cn4
Mecp2tm1Bird/Y
Tg(dlx5a-cre)1Mekk/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * CD-1 * FVB/N MGI:4999644
cn5
Cnr1tm1.2Ltz/Cnr1tm1.2Ltz
Tg(dlx5a-cre)1Mekk/?
involves: 129P2/OlaHsd * C57BL/6NCrl * CD-1 MGI:3758334
cn6
Cnr1tm1.2Ltz/Cnr1tm1.2Ltz
Tg(dlx5a-cre)1Mekk/?
involves: 129P2/OlaHsd * CD-1 MGI:3758337
cn7
Crhr1tm2Wrst/Crhr1tm2Wrst
Tg(dlx5a-cre)1Mekk/0
involves: 129S2/SvPas * C57BL/6J * CD-1 MGI:5294459


Genotype
MGI:5319088
cn1
Allelic
Composition
Ntrk1tm2.1Lfr/Ntrk1tm2.1Lfr
Tg(dlx5a-cre)1Mekk/0
Genetic
Background
involves: 129 * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk1tm2.1Lfr mutation (1 available); any Ntrk1 mutation (12 available)
Tg(dlx5a-cre)1Mekk mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• impaired cholinergic innervation into the frontal cortex at P7
• decrease in cholinergic fiber density and absence of a clear laminar pattern of innervation in the hippocampus at P14
• complete absence of cholinergic fibers in the hippocampus and only a small number of fibers in the frontal cortex at P90

behavior/neurological
• measurable decline in amygdala-dependent, but not hippocampal-dependent, cognitive performance
• significant decrease in recognition of a novel object




Genotype
MGI:5574069
cn2
Allelic
Composition
Cdkl5tm1.1Cogr/?
Tg(dlx5a-cre)1Mekk/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.1Cogr mutation (1 available); any Cdkl5 mutation (13 available)
Tg(dlx5a-cre)1Mekk mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice do not exhibit abnormal clasping or head tracking




Genotype
MGI:5574068
cn3
Allelic
Composition
Cdkl5tm1.1Cogr/Y
Tg(dlx5a-cre)1Mekk/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.1Cogr mutation (1 available); any Cdkl5 mutation (13 available)
Tg(dlx5a-cre)1Mekk mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice do not exhibit abnormal clasping or head tracking




Genotype
MGI:4999644
cn4
Allelic
Composition
Mecp2tm1Bird/Y
Tg(dlx5a-cre)1Mekk/0
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Bird mutation (2 available); any Mecp2 mutation (23 available)
Tg(dlx5a-cre)1Mekk mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice survive to at least 80 weeks of age

behavior/neurological
N
• mice show similar grooming times to controls
• mice have a nonsignificant trend to reduced total distance traveled
• time exhibiting aggressive behavior such as wrestling, tail-rattling, boxing, and mounting is similar to controls
• mice exhibit intact olfactory recognition and habituation in response to a novel odorant at 11 weeks of age
• at 12 weeks, mice have intact nociception demonstrated by a hot-plate or tail-flick assay
• mice show impaired maximum acoustic startle response to 120dB
• mice display more footslips, shorter latency to fall on wire, reduced number of side touches on dowel and shorter latency to fall from rotarod compared to controls
• mice show a 200% increase relative to control in number of holes explored with 2 or more sequential nose pokes in a holeboard assay
• nest building is impaired
• mice show increased social interaction with novel and familiar partners; time spent with novel partners is 60% higher than in controls in a 3-chamber assay

nervous system
• 24 week-old mice show increased prepulse inhibition at 74 dB

respiratory system
N
• mice show no alterations in tidal volume or minute volume, and display no apneas




Genotype
MGI:3758334
cn5
Allelic
Composition
Cnr1tm1.2Ltz/Cnr1tm1.2Ltz
Tg(dlx5a-cre)1Mekk/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6NCrl * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnr1tm1.2Ltz mutation (1 available); any Cnr1 mutation (24 available)
Tg(dlx5a-cre)1Mekk mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• depolarization-induced suppression of inhibition, as measured by evoked inhibitory postsynaptic current amplitude, is abolished

behavior/neurological
N
• 30 mg/kg kainic acid induces similar seizures as in wild-type mice and diazepam protects mice and wild-type mice similarly against kainic acid-induced seizures




Genotype
MGI:3758337
cn6
Allelic
Composition
Cnr1tm1.2Ltz/Cnr1tm1.2Ltz
Tg(dlx5a-cre)1Mekk/?
Genetic
Background
involves: 129P2/OlaHsd * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnr1tm1.2Ltz mutation (1 available); any Cnr1 mutation (24 available)
Tg(dlx5a-cre)1Mekk mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• probability that pyramidal cells will receive VGAT+/VGLUT3+ boutons in layer 2/3 of the neocortex is increased
• however, interneuron migration and neurochemical specification are normal




Genotype
MGI:5294459
cn7
Allelic
Composition
Crhr1tm2Wrst/Crhr1tm2Wrst
Tg(dlx5a-cre)1Mekk/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhr1tm2Wrst mutation (0 available); any Crhr1 mutation (17 available)
Tg(dlx5a-cre)1Mekk mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal anxiety-related behavior, forced swim test, and auditory fear conditioning

homeostasis/metabolism
N
• mice exhibit normal basal and stress-induced corticosterone levels





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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory