All Phenotypes Esrrb<tm1.2Nat> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Esrrb^tm1.2Nat
targeted mutation 1.2, Jeremy Nathans
MGI:3720482

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Esrrb^tm1.2Nat/Esrrb^tm1.2Nat	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL	MGI:3723506
cn2	Esrrb^tm1.1Nat/Esrrb^tm1.2Nat Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL	MGI:3723508
cn3	Esrrb^tm1.1Nat/Esrrb^tm1.2Nat Tg(Nes-cre)1Kln/0	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:3723507

Allelic Composition	Esrrb^tm1.2Nat/Esrrb^tm1.2Nat
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esrrb^tm1.2Nat mutation (0 available); any Esrrb mutation (211 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:124941 )

• no homozygous progeny are derived from Esrrb^tm1.2 heterozygous matings

Allelic Composition	Esrrb^tm1.1Nat/Esrrb^tm1.2Nat Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)
Esrrb^tm1.1Nat mutation (1 available); any Esrrb mutation (211 available)
Esrrb^tm1.2Nat mutation (0 available); any Esrrb mutation (211 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

absent startle reflex ( J:124941 )

• no auditory startle reflex

head bobbing ( J:124941 )

• observed beginning at several weeks of age

circling ( J:124941 )

• adults spin or run in circles

hearing/vestibular/ear

abnormal scala media morphology ( J:124941 )

• collapsed at 7 days of age

small scala media ( J:124941 )

• reduction in volume seen at 4 days of age

abnormal semicircular canal morphology ( J:124941 )

• narrowing of membranous labyrinths of the three semicircular canals is observed in postnatal animals

abnormal semicircular canal ampulla morphology ( J:124941 )

• flattening of ampullae is observed postnatally

decreased endolymph production ( J:124941 )

increased or absent threshold for auditory brainstem response ( J:124941 )

Allelic Composition	Esrrb^tm1.1Nat/Esrrb^tm1.2Nat Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esrrb^tm1.1Nat mutation (1 available); any Esrrb mutation (211 available)
Esrrb^tm1.2Nat mutation (0 available); any Esrrb mutation (211 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

absent strial marginal cells ( J:124941 )

• loss of strial margenial cells in mutants is observed; this leads to loss of intraepithelial capillaries

increased or absent threshold for auditory brainstem response ( J:124941 )

• ABR thresholds are variably elevated between 1 and 3 months of age

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