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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Del(11Cxcl16-Zmynd15)1Ifc
deletion, Chr 11, Israel F Charo
MGI:3720171
Summary 3 genotypes


Genotype
MGI:3721539
hm1
Allelic
Composition		 Del(11Cxcl16-Zmynd15)1Ifc/Del(11Cxcl16-Zmynd15)1Ifc
Genetic
Background		 B6.129S-Ldlrtm1Her Del(11Cxcl16-Zmynd15)1Ifc
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:123851 )
• uptake of 1,1'-dioctadecyl-3,3,3',3'-tetramethylin-docarbocyanin perchlorate (DiI)-LDL is reduced compared to in wild-type macrophages

hematopoietic system
abnormal macrophage physiology ( J:123851 )
• uptake of 1,1'-dioctadecyl-3,3,3',3'-tetramethylin-docarbocyanin perchlorate (DiI)-LDL is reduced compared to in wild-type macrophages




Genotype
MGI:4867174
hm2
Allelic
Composition		 Del(11Cxcl16-Zmynd15)1Ifc/Del(11Cxcl16-Zmynd15)1Ifc
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Spermatogenic disruption in the testes of Del(11Cxcl16-Zmynd15)1Ifc/Del(11Cxcl16-Zmynd15)1Ifc mice

reproductive system
reproductive system phenotype ( J:166802 )
N
• female mice exhibit normal fertility
increased male germ cell apoptosis ( J:166802 )
• of elongated spermatids, round spermatids, and spermatocytes
abnormal spermatogenesis ( J:166802 )
• mice exhibit disrupted spermatogenesis with depletion of elongated and round spermatids unlike in wild-type mice
azoospermia ( J:166802 )
• no spermatozoa are present in the cauda epididymis unlike in wild-type mice

endocrine/exocrine glands

cellular
azoospermia ( J:166802 )
• no spermatozoa are present in the cauda epididymis unlike in wild-type mice
increased male germ cell apoptosis ( J:166802 )
• of elongated spermatids, round spermatids, and spermatocytes




Genotype
MGI:3721540
cx3
Allelic
Composition		 Del(11Cxcl16-Zmynd15)1Ifc/Del(11Cxcl16-Zmynd15)1Ifc
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 B6.129S-Ldlrtm1Her Del(11Cxcl16-Zmynd15)1Ifc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(11Cxcl16-Zmynd15)1Ifc mutation (0 available); any Del(11Cxcl16-Zmynd15)1Ifc mutation (0 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
atherosclerotic lesions ( J:123851 )
• after 6 weeks, atherosclerosis lesions are 46% larger than in Ldlrtm1Her homozygotes
• after 10 weeks, atherosclerosis lesions are 27% and 56% (when assessed with serial sections of the aortic root stained with oil red O) larger than in Ldlrtm1Her homozygotes
• atherosclerotic lesions contain 80% more apoptotic cells than in Ldlrtm1Her homozygotes

cellular
increased apoptosis ( J:123851 )
• atherosclerotic lesions contain 80% more apoptotic cells than in Ldlrtm1Her homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory