Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cks1btm1Sir mutation
(0 available);
any
Cks1b mutation
(11 available)
|
|
|
reproductive system
N |
• males and females are fertile
|
growth/size/body
|
• mice are about 10% to 20% smaller than wild-type at E13.5 and continuing through adulthood
|
cellular
|
• derived MEF cells grow slower and senesced earlier than wild-type MEFs
|
Allelic Composition |
Cks1btm1Sir/Cks1b+
|
|
Genetic Background |
Not Specified |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cks1btm1Sir mutation
(0 available);
any
Cks1b mutation
(11 available)
|
|
|
growth/size/body
|
• intermediate decrease in body weight compared to Cks1btm1Sir homozygotes first noticeable during embryogenesis though to a lesser extent
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cks1btm1Sir mutation
(0 available);
any
Cks1b mutation
(11 available)
Tg(IghMyc)22Bri mutation
(1 available)
|
|
|
mortality/aging
|
• mean survival after lymphomas develop is 268 days compared to 91 days in Tg(IghMyc)22Bri mice and 101 days in Tg(IghMyc)22Bri Cks1btm1Sir heterozygotes
|
neoplasm
|
• only 1 of 9 diseased mice show moderate bone marrow infiltration and none presented with liver or meningeal infiltrates present in Tg(IghMyc)22Bri mice
|
|
• delayed development of lymphomas compared to Tg(IghMyc)22Bri mice
|
immune system
|
• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice
|
|
• 5.4+/-0.4x106ul compared to 6.9+/-0.4x106ul in Tg(IghMyc)22Bri mice
|
|
• at 4 weeks, mice have significantly smaller spleens than Tg(IghMyc)22Bri counter parts (83+/-11mg compared to 157+/-7mg)
|
hematopoietic system
|
• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice
|
|
• 5.4+/-0.4x106ul compared to 6.9+/-0.4x106ul in Tg(IghMyc)22Bri mice
|
|
• at 4 weeks, mice have significantly smaller spleens than Tg(IghMyc)22Bri counter parts (83+/-11mg compared to 157+/-7mg)
|
cellular
|
• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cks1btm1Sir mutation
(0 available);
any
Cks1b mutation
(11 available)
Tg(IghMyc)22Bri mutation
(1 available)
|
|
|
mortality/aging
|
• mean survival after lymphomas development is 101 days
|
neoplasm