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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cadps2tm1Tfr
targeted mutation 1, Teiichi Furuichi
MGI:3707315
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cadps2tm1Tfr/Cadps2tm1Tfr C57BL/6-Cadps2tm1Tfr MGI:3711235
ht2
Cadps2tm1Tfr/Cadps2+ C57BL/6-Cadps2tm1Tfr MGI:3711236


Genotype
MGI:3711235
hm1
Allelic
Composition
Cadps2tm1Tfr/Cadps2tm1Tfr
Genetic
Background
C57BL/6-Cadps2tm1Tfr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadps2tm1Tfr mutation (0 available); any Cadps2 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• granule cell migration through the cerebella is delayed (J:120106)
• granule cell migration through the cerebella is delayed (J:120106)
• mice exhibit several abnormal cell phenotypes in the brain (J:121256)
• mice exhibit several abnormal cell phenotypes in the brain (J:121256)
• at P17, there are significantly fewer parvalbumin+ interneurons in the neocortex (J:121256)
• however, this decrease can be rescued by BDNF injection (J:121256)
• at P17, there are significantly fewer parvalbumin+ interneurons in the neocortex (J:121256)
• however, this decrease can be rescued by BDNF injection (J:121256)
• the diameter of the presynapses are increased and the number of divided postsynaptic densities is increased (J:120106)
• the diameter of the presynapses are increased and the number of divided postsynaptic densities is increased (J:120106)
• at P17, the EGL remains thick when in wild-type it is barely visible (J:120106)
• however, by P28 the EGL is no longer detected (J:120106)
• the terminal buttons of parallel fibers (PF) are larger and vesicles around the extrasynaptic sites are reduced in number (J:120106)
• at P17, the EGL remains thick when in wild-type it is barely visible (J:120106)
• however, by P28 the EGL is no longer detected (J:120106)
• the terminal buttons of parallel fibers (PF) are larger and vesicles around the extrasynaptic sites are reduced in number (J:120106)
• Purkinje cells (PC) have a severe reduction in the extent of spiny dendritic arborization (J:120106)
• Purkinje cells (PC) have a severe reduction in the extent of spiny dendritic arborization (J:120106)
• mice have 41% of the calbindin+ Purkinje cells found in wild-type mice due to cell death (J:121256)
• however, this decrease can be rescued by BDNF treatment (J:121256)
• mice have 41% of the calbindin+ Purkinje cells found in wild-type mice due to cell death (J:121256)
• however, this decrease can be rescued by BDNF treatment (J:121256)
• intercrural fissures between lobules VI and VII are deficient (J:120106)
• intercrural fissures between lobules VI and VII are deficient (J:120106)
• cerebellar neuron differentiation is severely impaired (J:120106)
• arborization is reduced to about half the average length of wild-type (J:120106)
• apoptosis in cerebellar neurons is increased (J:120106)
• cerebellar neuron differentiation is severely impaired (J:120106)
• arborization is reduced to about half the average length of wild-type (J:120106)
• apoptosis in cerebellar neurons is increased (J:120106)
• HOKR phase is significantly delayed (J:120106)
• HOKR gain and plasticity is impaired (J:120106)
• HOKR phase is significantly delayed (J:120106)
• HOKR gain and plasticity is impaired (J:120106)

behavior/neurological
• deficits in circadian rhythmicity (J:121256)
• deficits in circadian rhythmicity (J:121256)
• mice explore less and/or exhibit increased anxiety when placed in a novel environment (J:121256)
• mice explore less and/or exhibit increased anxiety when placed in a novel environment (J:121256)
• mice explore less and/or exhibit increased anxiety when placed in a novel environment (J:121256)
• in an 8 arm radial maze mice show decreased locomotor activity and lower arm entries (J:121256)
• mice explore less and/or exhibit increased anxiety when placed in a novel environment (J:121256)
• in an 8 arm radial maze mice show decreased locomotor activity and lower arm entries (J:121256)
• when a novel object is placed within an open field mice are less active and make fewer contacts with the object (J:121256)
• when a novel object is placed within an open field mice are less active and make fewer contacts with the object (J:121256)
• retention of spatial memory in a Morris water maze test is impaired (J:121256)
• retention of spatial memory in a Morris water maze test is impaired (J:121256)
• HOKR phase is significantly delayed (J:120106)
• HOKR gain and plasticity is impaired (J:120106)
• HOKR phase is significantly delayed (J:120106)
• HOKR gain and plasticity is impaired (J:120106)
• performance on a rotarod treadmill is low to moderate (J:120106)
• however, by P56 mice perform normally (J:120106)
• performance on a rotarod treadmill is low to moderate (J:120106)
• however, by P56 mice perform normally (J:120106)
• deficits in sleep-wake regulation (J:121256)
• deficits in sleep-wake regulation (J:121256)
• female mice neglect newborns regardless of their genotype (J:121256)
• female mice neglect newborns regardless of their genotype (J:121256)
• frequency of social interactions when mice who have never interacted are placed within a cage for 20 minutes is decreased (J:121256)
• frequency of social interactions when mice who have never interacted are placed within a cage for 20 minutes is decreased (J:121256)

growth/size/body

cellular
• granule cell migration through the cerebella is delayed (J:120106)
• granule cell migration through the cerebella is delayed (J:120106)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:121256




Genotype
MGI:3711236
ht2
Allelic
Composition
Cadps2tm1Tfr/Cadps2+
Genetic
Background
C57BL/6-Cadps2tm1Tfr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadps2tm1Tfr mutation (0 available); any Cadps2 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in an 8 arm radial maze mice show an intermediate phenotype compared to homozygotes (J:121256)
• in an 8 arm radial maze mice show an intermediate phenotype compared to homozygotes (J:121256)
• mice exhibit an intermediate lack of nurturing phenotype (J:121256)
• mice exhibit an intermediate lack of nurturing phenotype (J:121256)





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory