All Phenotypes Marchf1<tm1.1Sish> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Marchf1^tm1.1Sish/Marchf1^tm1.1Sish	involves: 129S1/Sv * 129X1/SvJ	MGI:4436872
cx2	H2^dlAb1-Ea/H2^dlAb1-Ea Marchf1^tm1.1Sish/Marchf1^tm1.1Sish	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:4436870
cx3	Cd86^tm1Shr/Cd86^tm1Shr Marchf1^tm1.1Sish/Marchf1^tm1.1Sish	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:4436871
cx4	Cd83^tm1.1Lnjt/Cd83^tm1.1Lnjt Marchf1^tm1.1Sish/Marchf1^tm1.1Sish	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N	MGI:5903300

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:201198 )

N	• regulatory T cells exhibit normal cell proliferation and survival

abnormal T cell differentiation ( J:201198 )

• dendritic cell-intrinsic reduction in regulatory T cell development from bone marrow cells transplanted into irradiated host mice

• however, deletion of blood-borne, antigen-specific CD4 single positive thymocytes is normal

decreased regulatory T cell number ( J:201198 )

abnormal dendritic cell morphology ( J:119918 )

• splenic dendritic cells show increased MHC class II surface expression relative to wild-type

abnormal B cell physiology ( J:119918 )

• internalization of MHC class II surface molecules appears to be greater in mutants relative to wild-type

• internalized MHC class II molecules are localized to the recycling compartment, while in wild-type, these molecules localize to the lysosomal compartment

abnormal dendritic cell antigen presentation ( J:157516 , J:201198 )

• dendritic cells are unable to present a GFP-fused I-Ealpha antigen unlike similarly treated wild-type mice (J:157516)

• increased (J:201198)

abnormal level of surface class II molecules ( J:119918 )

• MHC class II molecule surface expression is upregulated in blood-circulating B cells

decreased interleukin-12 secretion ( J:157516 )

• in CD8+ and CD8- dendritic cells following LPS or anti-CD40 antibody stimulation

decreased tumor necrosis factor secretion ( J:157516 )

• in CD8+ and CD8- dendritic cells following LPS or anti-CD40 antibody stimulation

hematopoietic system

abnormal T cell differentiation ( J:201198 )

• dendritic cell-intrinsic reduction in regulatory T cell development from bone marrow cells transplanted into irradiated host mice

• however, deletion of blood-borne, antigen-specific CD4 single positive thymocytes is normal

decreased regulatory T cell number ( J:201198 )

abnormal dendritic cell morphology ( J:119918 )

• splenic dendritic cells show increased MHC class II surface expression relative to wild-type

abnormal B cell physiology ( J:119918 )

• internalization of MHC class II surface molecules appears to be greater in mutants relative to wild-type

• internalized MHC class II molecules are localized to the recycling compartment, while in wild-type, these molecules localize to the lysosomal compartment

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Marchf1^tm1.1Sish/Marchf1^tm1.1Sish
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (280 available)
Marchf1^tm1.1Sish mutation (1 available); any Marchf1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:157516 )

N	• stimulated dendritic cells produce normal amounts of IL-12 and TNF-alpha

Allelic Composition	Cd86^tm1Shr/Cd86^tm1Shr Marchf1^tm1.1Sish/Marchf1^tm1.1Sish
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd86^tm1Shr mutation (9 available); any Cd86 mutation (38 available)
Marchf1^tm1.1Sish mutation (1 available); any Marchf1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-12 secretion ( J:157516 )

• in dendritic cells following LPS or anti-CD40 antibody stimulation

decreased tumor necrosis factor secretion ( J:157516 )

• in dendritic cells following LPS or anti-CD40 antibody stimulation

Allelic Composition	Cd83^tm1.1Lnjt/Cd83^tm1.1Lnjt Marchf1^tm1.1Sish/Marchf1^tm1.1Sish
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd83^tm1.1Lnjt mutation (0 available); any Cd83 mutation (15 available)
Marchf1^tm1.1Sish mutation (1 available); any Marchf1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:236611 )

• in the thymus as in Cd83^tm1.1Lnjt homozygotes

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:236611 )

• in the thymus as in Cd83^tm1.1Lnjt homozygotes

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