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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
transgene insertion 6799, Robert Vassar
MGI:3693208
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Qpcttm1.2Tbay/Qpcttm1.2Tbay
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
B6.Cg-Qpcttm1.2Tbay Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas MGI:4941718
cx2
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Tg(Prnp-MAPT*P301S)PS19Vle/0
B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas Tg(Prnp-MAPT*P301S)PS19Vle MGI:5629689
cx3
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Tg(Thy1-QPCT)#Tbay/0
B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas Tg(Thy1-QPCT)#Tbay MGI:4941719
cx4
Apoa4tm1Bres/Apoa4tm1Bres
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
involves: 129S4/SvJae * C57BL/6 * SJL MGI:5051942
cx5
Cdk5r1tm2.1Lht/?
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:5560900
cx6
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Tg(Thy1-MAPT*)30Schd/0
involves: C57BL/6 * C57BL/6J * CBA * SJL MGI:5559229
tg7
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas MGI:5755045
tg8
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0 B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas MGI:5755043
tg9
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0 B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax MGI:5604616
tg10
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0 involves: C57BL/6 * C57BL/6J * CBA * SJL MGI:5559228
tg11
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0 involves: C57BL/6 * SJL MGI:3693295
tg12
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/? involves: 129S4/SvJae * C57BL/6 * SJL MGI:5051941
tg13
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/? involves: C57BL/6 * SJL MGI:5560912


Genotype
MGI:4941718
cx1
Allelic
Composition
Qpcttm1.2Tbay/Qpcttm1.2Tbay
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Genetic
Background
B6.Cg-Qpcttm1.2Tbay Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qpcttm1.2Tbay mutation (0 available); any Qpct mutation (7 available)
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 6 months, mice exhibit a lower plaque load than Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mice

behavior/neurological
N
• spatial working memory defects observed in Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mice are rescued
• mice exhibit improved motor coordination on a beam or when suspended by a string compared with Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mice

homeostasis/metabolism
• at 6 months, mice exhibit a lower plaque load than Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mice




Genotype
MGI:5629689
cx2
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Tg(Prnp-MAPT*P301S)PS19Vle/0
Genetic
Background
B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas Tg(Prnp-MAPT*P301S)PS19Vle
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mutation (0 available)
Tg(Prnp-MAPT*P301S)PS19Vle mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice develop extracellular amyloid plaque to a similar extent as mice expressing only the Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas trasngene

nervous system
• mice develop extracellular amyloid plaque to a similar extent as mice expressing only the Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas trasngene
• hippocampal atrophy in aged mice
• mice show aggravation of hyperphosphorylated tau pathology that is already seen at 3 months of age
• mossy fiber degeneration by 9 months of age
• mice show reduced number of CA1 neurons at 9 months of age compared to either single mutant, indicating increased loss of hippocampal CA1 neurons
• mice show increased astrocytosis in the cortex and thalamus at 3 months of age, and by 9 months of age, astrocytosis is strongly elevated in the hippocampus
• aged mice show a decrease in apical dendrite density in the hippocampal stratum radiatum
• increase in loss of synapses

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:211723




Genotype
MGI:4941719
cx3
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Tg(Thy1-QPCT)#Tbay/0
Genetic
Background
B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas Tg(Thy1-QPCT)#Tbay
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit decreased alternation frequency in a Y maze compared with Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mice
• mice exhibit impaired motor coordination on a beam or when suspended by a string compared with Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mice

nervous system
• at 6 months, mice exhibit a higher plaque load than Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mice

homeostasis/metabolism
• at 6 months, mice exhibit a higher plaque load than Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mice




Genotype
MGI:5051942
cx4
Allelic
Composition
Apoa4tm1Bres/Apoa4tm1Bres
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa4tm1Bres mutation (1 available); any Apoa4 mutation (7 available)
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• impaired survival compared to wild-type mice and transgenic mice wild-type for Apoa4

nervous system
• accelerated deposition compared to transgenic mice wild-type for Apoa4
• large pyramidal neurons in cortical layer 5 and neurons in hippocampus contain more disrupted morphologies indicating enhanced neuron loss compared to transgenic mice wild-type for Apoa4
• loss of neurons is increased in areas of the cortex and CA1, CA3 of the hippocampus

behavior/neurological
• impaired spatial learning (slower decrease in escape latency during training in a morris water maze) compared to transgenic mice wild-type for Apoa4
• more time spent in the incorrect quadrant in a probe trial in a morris water maze compared to transgenic mice wild-type for Apoa4

homeostasis/metabolism
• accelerated deposition compared to transgenic mice wild-type for Apoa4

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:169682




Genotype
MGI:5560900
cx5
Allelic
Composition
Cdk5r1tm2.1Lht/?
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5r1tm2.1Lht mutation (1 available); any Cdk5r1 mutation (4 available)
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• long term depression is restored to wild type levels as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
• anxiety, cognitive performance and contextual/cued fear conditioning are restored to wild type levels as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas

nervous system
N
• presence of reactive astrocytes and activated microglia is close to wild type levels as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
• plaque load in the hippocampus is reduced as compared to mice with Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone, but still higher than wild type
• 20-30% reduction of levels of Abeta42 and Abeta40 in the hippocampus as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas

homeostasis/metabolism
• plaque load in the hippocampus is reduced as compared to mice with Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone, but still higher than wild type
• 20-30% reduction of levels of Abeta42 and Abeta40 in the hippocampus as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas




Genotype
MGI:5559229
cx6
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Tg(Thy1-MAPT*)30Schd/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• decreased survival at 10 months of age

nervous system
• plaque load is reduced compared to mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone
• at 9 months of age compared to wild-type mice and mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone
• detected in the hippocampus, cortex, and spinal cord
• tangles in hippocampal neurons are composed of straight filaments with a wavy appearance and of occasional paired helical filaments
• density of tangles in the spinal cord increases strongly from 3 to 9 months of age
• density of tangles in the hippocampus and cortex is increased compared to mice hemizygous for Tg(Thy1-MAPT*)30Schd alone
• age of onset of tangles is earlier compared to mice hemizygous for Tg(Thy1-MAPT*)30Schd alone
• dilated dystrophic neurites at 9 months of age

behavior/neurological
• at 6 and 8 months of age compared to wild-type mice and mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone
• impairment is more severe than in mice hemizygous for Tg(Thy1-MAPT*)30Schd alone

growth/size/body
• significant and progressive reduction in body weight starting at 6 months of age

homeostasis/metabolism
• plaque load is reduced compared to mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:201809




Genotype
MGI:5755045
tg7
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
Genetic
Background
B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• impaired acquisition in 2 and 5 month old females; escape latencies increase over 5 days of training
• impaired spacial reference memory in 5 month old females
• increased open to total arm entry ratio in 2 and 5 month old females
• loss of normal anxiety phenotype
• increased clasping behavior during tail suspension in 5 month old females
• impairment in balance and general motor coordination in 5 month old females as measured by the balance beam
• 9 month old males either remain still on balance beam or fall off due to hind limb paresis
• poor performance in string suspension paradigm as compared to wild-type and female hemizygotes at 5 months of age
• impairment in balance and general motor coordination in 5 month old females as measured by the balance beam
• decreased average swimming speed during cued training in 5 month old females, however no difference in day 3 escape latency
• postural abnormalities observed in 9 month old males
• hind limb paresis in 9 month old males
• in females older than 5 months of age

growth/size/body
• reduced body weight in 2 and 5 month old females
• wasting observed in 9 month old males

homeostasis/metabolism
• increased plaque load in cortex, hippocampus and thalamus at 2 (females), 5 (females) and 9 (males) months
• increase in plaque load in spinal cord of 9 month old males
• increased TBS-soluble Abeta1-42 and Abeta1-40 levels at 2 and 5 months (females) as compared to hemizygotes
• increased SDS-soluble Abeta1-42 levels at 2 and 5 months (females) as compared to hemizygotes
• increased extracellular plaque load and intracellular Abeta immunoreacitivy in large spinal cord neurons in 9 month old males

nervous system
• increased plaque load in cortex, hippocampus and thalamus at 2 (females), 5 (females) and 9 (males) months
• increase in plaque load in spinal cord of 9 month old males
• increased TBS-soluble Abeta1-42 and Abeta1-40 levels at 2 and 5 months (females) as compared to hemizygotes
• increased SDS-soluble Abeta1-42 levels at 2 and 5 months (females) as compared to hemizygotes
• increased extracellular plaque load and intracellular Abeta immunoreacitivy in large spinal cord neurons in 9 month old males
• increase in axonal swellings in pons and gray matter of spinal cord of 9 month old male homozygotes as compared to hemizygotes

reproductive system
• in females older than 5 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:229382




Genotype
MGI:5755043
tg8
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Genetic
Background
B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• increased open to total arm entry ratio in 5 month old females, however, phenotype is more severe in homozygotes
• increased clasping during tail suspension in 5 month old females as compared to controls, however clasping in homozygotes is more severe

growth/size/body
• reduced body weight at 2 months old females, but weight is similar to control by 5 months of age




Genotype
MGI:5604616
tg9
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Genetic
Background
B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• retinal amyloid beta accumulates in the retinal pigment epithelial (RPE) layer and amyloid beta deposits are seen beneath the RPE layer

nervous system
• retinal amyloid beta accumulates in the retinal pigment epithelial (RPE) layer and amyloid beta deposits are seen beneath the RPE layer

pigmentation
• abundant intracellular amyloid beta is seen in the cytosol of RPE and with increasing intracellular accumulation of amyloid beta, tight junction integrity is attenuated and disorganized
• 12 month old mutants show hypopigmentation in the RPE layer

vision/eye
• drusen-like deposit is seen between the retinal pigment epithelium (RPE) layer and Bruch membrane in 12 month old mutants
• large vacuoles are seen in the retina of 12 month old mutants
• abundant intracellular amyloid beta is seen in the cytosol of RPE and with increasing intracellular accumulation of amyloid beta, tight junction integrity is attenuated and disorganized
• 12 month old mutants show hypopigmentation in the RPE layer
• thickened Bruch membrane is seen in the retina of 12 month old mutants

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:214858




Genotype
MGI:5559228
tg10
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• decreased survival at 10 months of age

nervous system

homeostasis/metabolism




Genotype
MGI:3693295
tg11
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• by 4-5 months of age, defects in Y-maze alternation are detected in transgenic mice, indicating impaired spatial learning/memory

nervous system
• mice show Abeta42 deposits at 2 months of age; Abeta40 levels are lower in amyloid deposits; mice show robust intraneuronal amyloid deposition
• amyloid deposition increases rapidly with increasing age
• plaques appear first in deep cortical layers and in subiculum, and spread with age to fill most of cortex, subiculum and hippocampus; also, less numerous deposits are observed in thalamus, brainstem and olfactory bulb in older mice
• transgenic mice display neuroinflammation
• cortical layer 1 is significantly thinner than in control brains
• neurons in subiculum are very pale, or absent
• microgliosis and astrogliosis is seen in plaque-bearing regions of the brain by 2 months of age; numbers of activated astrocytes and microglia increases with age
• some neurons contain intraneuronal aggregates and display disrupted morphology
• large neurons in cortical layer 5 are reduced in number
• synapse degeneration begins at 4 months of age, compared to nontransgenic controls, as shown by reduction in levels of synaptic markers; neurodeneration marker p25 level is ~150% of control at 9 and 12 months

immune system
• transgenic mice display neuroinflammation

homeostasis/metabolism
• mice show Abeta42 deposits at 2 months of age; Abeta40 levels are lower in amyloid deposits; mice show robust intraneuronal amyloid deposition
• amyloid deposition increases rapidly with increasing age
• plaques appear first in deep cortical layers and in subiculum, and spread with age to fill most of cortex, subiculum and hippocampus; also, less numerous deposits are observed in thalamus, brainstem and olfactory bulb in older mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:112949
Alzheimer Disease; AD 104300 J:112949




Genotype
MGI:5051941
tg12
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• impaired survival compared to wild-type mice
• survive longer than transgenic mice that are also Apoa4 null

nervous system

homeostasis/metabolism

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:169682




Genotype
MGI:5560912
tg13
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• decreased % of time freezing in contextual fear conditioning test
• decreased % of time freezing in cued fear conditioning test
• poor novel object recognition

hematopoietic system
• increased percentage of activated microglia as compared to controls

immune system
• increased percentage of activated microglia as compared to controls

nervous system
• increased percentage of activated microglia as compared to controls
• increased plaque load and size as compared to controls
• high levels of Abeta42 and Abeta40 in the hippocampus as compared to mice that also carry Cdk5r1tm2.1Lht
• increased percentage of reactive astrocytes as compared to controls
• decreased magnitude of long term depression as compared to controls

homeostasis/metabolism
• increased plaque load and size as compared to controls
• high levels of Abeta42 and Abeta40 in the hippocampus as compared to mice that also carry Cdk5r1tm2.1Lht





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory