Qpct^tm1.2Tbay
Targeted Allele Detail

Summary

• Symbol: Qpct^tm1.2Tbay
• Name: glutaminyl-peptide cyclotransferase (glutaminyl cyclase); targeted mutation 1.2, Thomas A Bayer
• MGI ID: MGI:4941596
• Gene: Qpct Location: Chr17:79359335-79397807 bp, + strand Genetic Position: Chr17, 49.83 cM, cytoband E3
• Alliance: Qpct^tm1.2Tbay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169481
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted into intron 3 and 5. Flp-mediated recombination removed the FRT-flanked neo cassette, and cre-mediated recombination removed exons 4 and 5. The absence of transcript expression was confirmed by RT-PCR. (J:169481)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Qpct Mutation: 8 strains or lines available

References

• Original: J:169481 Jawhar S, et al., Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice. J Biol Chem. 2011 Feb 11;286(6):4454-60
• All: 4 reference(s)