Phenotypes associated with this allele
integument
N |
• mutants do not develop hamartomas over a period of 300 days and epidermal thickness is normal at 8 weeks of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation
(1 available);
any
Pik3ca mutation
(62 available)
Ptentm1Hwu mutation
(16 available);
any
Pten mutation
(81 available)
Tg(KRT14-cre)#Smr mutation
(0 available)
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integument
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• expanded basal cell layers
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• development of skin lesions is delayed and severity is reduced compared to single Pten mutants
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• skin is thickened at 8 weeks of age, but to a lesser extent than in single Pten mutants
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• develop skin hamartomas with a median latency of 121 days
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neoplasm
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• develop skin hamartomas with a median latency of 121 days
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation
(1 available);
any
Pik3ca mutation
(62 available)
Tg(Pbsn-cre)4Prb mutation
(2 available)
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cellular
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• following cre-mediated recombination, mouse embryonic fibroblasts (MEFs) undergo reduced levels of immortalization upon exposure to HRas-G12V or EGFR-Del from feeder cells
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neoplasm
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• mice develop prostate intraepithelial neoplasias
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reproductive system
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• mice develop prostate intraepithelial neoplasias
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endocrine/exocrine glands
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• mice develop prostate intraepithelial neoplasias
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation
(1 available);
any
Pik3ca mutation
(62 available)
Tg(OPN1LW-cre)4Yzl mutation
(1 available)
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vision/eye
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• cone cell loss in 3 month old mice
• however, overall morphology and structural integrity of retinas is normal at 3 months of age
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• photopic ERG b-wave recordings of cone photoreceptors are lower at 3 months of age
• however, scotopic ERG recordings of rod photoreceptors are normal at 3 months of age
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nervous system
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• cone cell loss in 3 month old mice
• however, overall morphology and structural integrity of retinas is normal at 3 months of age
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